Description
Hemophilia and Von Willebrand Disease: Factor VIII and Von Willebrand Factor serves as a must-have reference on the important role these essential blood-clotting proteins play in research and clinical medicine. Clinicians and researchers face the daily challenge of staying current on the vast amounts of research that is now generated. The reference to Janus in the title refers to the two roles of the Factor VIII/Von Willebrand Factor Complex: initiation of coagulation and propagation of clot formation. The complex prevents bleeding in hemophilia and Von Willebrand disease but also augments arterial and venous thrombosis.- Presents one source of information on Hemophilia and Von Willebrand Disease, as well as Factor VIII and Von Willebrand Factor, eliminating the search through hundreds of journal articles- Combines the multi-disciplinary research that is generated from Factor VIII/Von Willebrand Factor – hematology, drug discovery, genetics, cell biology, and oncology- Delves into unanswered questions and future directions of this important blood-clotting complex
Table of Contents
1. Historical Background2. Factor VIII: Anatomy and Physiology3. Genetic Basis of Hemophilia4. Factor VIII Therapy for Bleeding5. Complications of Therapy6. Acquired Disorders of Factor VIII7. Factor VIII and Thrombosis8. Factor VIII: Future Directions
