Description
The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics.
Table of Contents
Current Immune Aspects of Biologics and Nanodrugs: An Overview
Raj Bawa, MS, PhD
Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox
János Szebeni, MD, PhD, DSc, and Raj Bawa, MS, PhD
Immunotherapy and Vaccines
Johanna Poecheim, PhD, and Gerrit Borchard, PhD
Site-Specific Antibody Conjugation for ADC and Beyond
Qun Zhou, PhD
Current Understanding of Interactions between Nanoparticles and the Immune System
Marina A. Dobrovolskaia, PhD, Michael Shurin, MD, PhD, and Anna A. Shvedova, PhD
Auto-antibodies as Biomarkers for Disease Diagnosis
Angelika Lueking, Heike Göhler, and Peter Schulz-Knappe
The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers
Amr S. Abu Lila, PhD, and Tatsuhiro Ishida, PhD
Anti-PEG Immunity Against PEGylated Therapeutics
Amr S. Abu Lila, PhD, and Tatsuhiro Ishida, PhD
Complement Activation: Challenges to Nanomedicine Development
Dennis E. Hourcade, PhD, Christine T. N. Pham, MD, and Gregory M. Lanza, MD, PhD
Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation
Milan Basta, MD, PhD
Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols
Rudolf Urbanics, MD, PhD, Péter Bedőcs, MD, PhD, and János Szebeni, MD, PhD
Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions
Zsófia Patkó, MD, PhD, and János Szebeni, MD, PhD, DSc
Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms
László Dézsi, PhD, László Rosivall, MD, PhD, Péter Hamar, MD, PhD, János Szebeni, MD, PhD, and Gábor Szénási, PhD
Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities
Kaushik Thanki, PhD, Emily Falkenberg, Monique Gangloff, PhD, and Camilla Foged, PhD
Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA
Ranjita Shegokar, PhD, and Prabhat Mishra, PhD
Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism Erin J. van Schaik, PhD, Anthony E. Gregory, PhD, Gerald F. Audette, PhD, and James E. Samuel, PhD
Immunogenicity Assessment for Therapeutic Protein Products
Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products
The "Sentinel": A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System
Frank J. Boehm and Angelika Domschke, PhD
Immunotherapy for Gliomas and Other Intracranial Malignancies
Mario Ganau, MD, PhD, Gianfranco K. I. Ligarotti, MD, Salvatore Chibbaro, MD, PhD, and Andrea Soddu, PhD
Engineering Nanoparticles to Overcome Barriers to Immunotherapy
Randall Toy, PhD, and Krishnendu Roy, PhD
Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications
Yueh-Hsia Luo, PhD, Louis W. Chang, PhD, and Pinpin Lin, PhD
Silica Nanoparticles Effects on Hemostasis
Volodymyr Gryshchuk, PhD, Volodymyr Chernyshenko, PhD, Tamara Chernyshenko, Olha Hornytska, PhD, Natalya Galagan, PhD, and Tetyana Platonova, DrSc
Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia
Prabha S. Awale, PhD, James C. K. Lai, PhD, Srinath Pashikanthi, PhD, and Alok Bhushan, PhD
Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin
Amr S. Abu Lila, Janos Szebeni, and Tatsuhiro Ishida
Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines
Matthias Bartneck, PhD
Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation
Cristina Fornaguera, MSc, PhD
Unwanted Immunogenicity: From Risk Assessment to Risk Management
Cheryl Scott
Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials
Minnie Au, MBBS, Theophilus I. Emeto, PhD, Jacinta Power, MBBS, Venkat N. Vangaveti, PhD, and Hock C. Lai, MBBS
SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy
Joe B. Harford, PhD, Sang-Soo Kim, PhD, Kathleen F. Pirollo, PhD, Antonina Rait, PhD, and Esther H. Chang, PhD
