Description
Neurocritical Care Pharmacotherapy: A Clinican's Guide is a practical, succinct but comprehensive pharmacy handbook provides up-to-date clinical guidance on the effective selection, prescription, and usage of neurocritical care drugs for patients with acute neurologic illnesses. The treatment of the critically ill neurologic patient is often difficult, specialized, and includes drugs infrequently used in other intensive care units such as antiepileptic drugs, osmotic agents or acute immunotherapy such as intravenous immunoglobulin and plasma exchange.This text discusses choosing the right combination of drugs; how to correctly prescribe and administer the drugs; how to monitor drug efficacy and side effects; how neurocritical care drugs interact with other medications; and comprehensive coverage of current treatment options.Key Feature of this Manual Include· A brief discussion of the basic pharmacology of each neurocritical drug, with an emphasis on how to select and use these drugs in multiple clinical contexts.· 150 drugs accompanied by a diagram for quick comprehension and drug administration guides.· Unique blending of expertise of neurointensivist with a critical care pharmacist to provide a vital resource for both specialities· References for further reading that are oriented toward utility in clinical practice.
Table of Contents
PrefaceChapter 1: Drug Delivery, Monitoring and InteractionsBioavailability of a DrugDrug Administration RoutesDrug InteractionsDrug ErrorsPharmacogenomicsNeuropharmacology and Critical Care PharmacologyChapter 2: Analgosedation and Neuromuscular BlockersDeciding on SedationSedative DrugsAnalgesicsNeuromuscular BlockersNeuromuscular Blockers in ICU PracticeNeuromuscular Blockers ReversalChapter 3: Agitation and DeliriumCauses of deliriumClinical Features of DeliriumPharmacologic Treatment of AgitationNeurolepticsBenzodiazepinesPreventive DrugsChapter 4: Pain ManagementGrading PainTypes of Pain in the Neurosciences ICUIndications for Pain ManagementDrugs for painNon-steroidal Anti-Inflammatory AgentsPatient-controlled AnalgesiaChapter 5: Osmotic TherapyThe Constants of Brain VolumeHyperosmolar FluidsOsmotic Agents in Clinical PracticeChapter 6: Antiepileptic drugsSeizures in the ICUTreatment ProtocolsAntiepileptic Drugs Used in ICU PracticeInteractions and AdjustmentsChapter 7: Anticoagulation and Reversal DrugsAnticoagulation and StrokeHeparin and WarfarinFactor Xa InhibitorsThrombin InhibitorsHemorrhage from AnticoagulantsCurrent Recommendations on Reversal AgentsChapter 8: Antifibrinolytics and ThrombolyticsBasic Mechanisms and TargetsAntifibrinolyticsFibrinolyticsThrombolyticsPost-alteplase CareChapter 9: Antiplatelet AgentsClinical Trials on Antiplatelet Agents in StrokeCurrent Indications for Antiplatelet AgentsAntiplatelet AgentsTesting Platelet FunctionAntiplatelet ResistanceDiscontinuation Antiplatelet Agents before ProcedureClinical Urgency While on AntiplateletsChapter 10: Immunosuppression and ImmunotherapyCorticosteroidsPlasma ExchangeIntravenous ImmunoglobulinCheck Point Inhibitor ImmunotherapyOther Therapeutic Targets in Autoimmune NeurologyChapter 11: Antimicrobial Therapy for CNS infectionsBacterial MeningitisViral, Fungal, and Parasitic InfectionsThe Pharmacology of AntibioticsAntiviralsAntifungalsChapter 12: Vasopressors and InotropesMechanisms of Action in Vasopressors and InotropesVasopressorsInotropesUse in Clinical PracticeChapter 13: Antihypertensives and AntiarrhythmicsDefinition of Hypertension and Blood Pressure GoalsBest Practice of AntihypertensivesControl of Blood Pressure after Urgent ControlAntiarrhythmic DrugsChapter 14: Fluid TherapyRegulation of Fluid StatusGeneral Principles of Fluid ManagementType of FluidsFluid AdministrationFluid Management Principles in the NICUAcute Fluid ResuscitationChapter 15: Drugs to Correct Electrolyte and Acid Base DisordersCommon Electrolyte ReplacementsDisorders of Sodium and Water homeostasisDrugs to manage Sodium DisordersChapter 16: Antidotes with OverdoseFirst Treatment ConsiderationsToxins and Major Laboratory AbnormalitiesNeurology of OverdoseCommonly Used Agents for DetoxificationMajor ToxidromesToxic DysautonomiasChapter 17: Drugs for Prevention of ComplicationsPrevention of Deep Venous ThrombosisPrevention of HyperglycemiaPrevention of Stress UlcersPrevention of InfectionsPrevention of Cerebral vasospasmChapter 18: Withdrawal Syndromes and TreatmentAlcohol Withdrawal SyndromeOpioid WithdrawalStimulant WithdrawalBaclofen WithdrawalNicotine WithdrawalChapter 19: Treatment of Brain Injury-associated Symptoms and SignsControl of Specific HeadachesControl of Nausea and VomitingControl of HiccupsControl of SecretionsControl of Constipation and DysmotilityControl of Fever and ShiveringControl of RhabdomyolysisChapter 20: Drugs used in NeurorehabilitationNeurostimulantsDrugs for post- stroke depressionDrugs for spasticityIndex
