Description
Vitamin D: Volume One: Biochemistry, Physiology and Diagnostics, Fourth Edition, presents the latest information from international experts in endocrinology, bone biology and human physiology, taking readers through the basic research of vitamin D.This impressive reference presents a comprehensive review of the multifaceted vitamin D. Researchers from all areas will gain insight into how clinical observations and practices can feed back into the research cycle, thus allowing them to develop more targeted genomic and proteomic insights on the mechanisms of disease.- Offers a comprehensive reference, ranging from basic bone biology, to biochemistry, to the clinical diagnostic and management implications of vitamin D- Saves researchers and clinicians time in quickly accessing the very latest details on the diverse scientific and clinical aspects of Vitamin D, as opposed to searching through thousands of journal articles- Targets chemistry, metabolism and circulation, mechanisms of action, mineral and bone homeostasis, human physiology, diagnosis and management, nutrition, sunlight, genetics and vitamin D deficiency- Volume II of this collection presents a clinical focus on disorders, analogs, cancer; immunity, inflammation and disease and therapeutic applications
Table of Contents
Volume 1: Biochemistry, Physiology and DiagnosticsIn Memoriam: Robert P. Heaney, MD (1928-2016)In Memoriam: Milan Uskokovic, PhD (1924-2015)Section I. History, Chemistry Metabolism, Circulation & Regulation1. Historical Overview of Vitamin D2. Evolutionary Biology: Mysteries of Vitamin D in Fish3. Evolution of Human Skin Color and Vitamin D4. Photobiology of Vitamin D5. The Activating Enzymes of Vitamin D Metabolism (25- and 1a-Hydroxylases)6. CYP24A1: Structure, Function, and Physiological Role7. The Vitamin D Binding Protein DBP8. Regulation of renal and extra-renal 1a-hydroxylaseSection II. Mechanism of Action9. Genome-Wide Perspectives on Vitamin D Receptor-Meditated Control of Gene Expression in Target Cells 10. Diverse mechanisms of transcriptional regulation by the vitamin D receptor11. Structural basis for ligand activity in VDR12. Ligand Independent Actions of Vitamin D Receptor13. Vitamin D and Chromatin14. Mesenchymal Differentiation, Epigenetic Dynamics, and Interactions with VDR15. Vitamin D and microRNAs16. Vitamin D Sterol/VDR Conformational Dynamics and Nongenomic ActionsSection III. Mineral and Bone Homeostasis17. Vitamin D Regulation of Osteoblast Function18. Osteoclastogenesis and Vitamin D19. Vitamin D Activities in Osteocytes20. Regulation of Intestinal Calcium and Phosphate Absorption21. Calbindin-D28K and Calbindin-D9K and the Epithelial Calcium Channels TRPV5 and TRPV622. Calcium homeostasis and eggshell biomineralization in female chicken23. Mineralization in Mammals24. Cartilage25. Vitamin D and Bone: An Integrated ApproachSection IV. Extra-Skeletal Targets26. Vitamin D and the Kidney27. Vitamin D and the Parathyroids28. The Calcium-sensing Receptor and Vitamin D29. Vitamin D in Dentoalveolar and Oral Health30. The Role of Vitamin D and its Receptor in Hair Follicle Biology31. Vitamin D, Calcium and the Epidermis32. Vitamin D and the Cardiovascular System33. Vitamin D Brain Development and Function34. Vitamin D, VDR and Adipose Tissue: Focus on Cellular Mechanisms35. Vitamin D and Skeletal Muscle36. Understanding Vitamin D from mouse knockout modelsSection V. Human Physiology37. Pharmacology and pharmacokinetics38. Vitamin D Role in the Calcium and Phosphorus Economies39. Fetus, Neonate and Infant40. Consequences of perinatal vitamin D deficiency on later bone health41. Adolescence and Acquisition of Peak Bone Mass42. Pregnancy, Lactation, and Post-Weaning Recovery43. Role in Reproductive Biology and Reproductive Dysfunction in Women44. Vitamin D, reproductive biology, and dysfunction in men45. Vitamin D and the Renin-Angiotensin System46. Parathyroid Hormone, Parathyroid Hormone-Related Protein, and Calcitonin47. FGF23 Counter Regulatory Hormone for Vitamin D Actions on Mineral Metabolism, Hemodynamics, and L. Darryl QuarlesSection VI. Diagnosis and Management48. Approach to the Patient with Metabolic Bone Disease49. Detection of 1,25-Dihydroxyvitamin D in Human Serum using Receptor Assisted Chemiluminescent Hormone Assay (REACH) Technology50. Mass Spectrometry Assays of Vitamin D Metabolites51. Free Vitamin D: Concepts, Assays, Outcomes and Prospects52. 25-Hydroxyvitamin D Assays: Standardization Guidelines, Problems and Interpretation53. Bone Histomorphometry54. Radiology of Rickets and Osteomalcia55. High-resolution Imaging Techniques for Bone Quality Assessment56. The Role of Vitamin D in Orthopedic Surgery57a. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the IOM Position57b. The IOM-Endocrine Society Controversy on Recommended Vitamin D Targets: In Support of the Endocrine Society Position
