Description
This book provides a comprehensive overview of current immunotherapy strategies, and how these may be applicable to childhood cancers. The first part of the book reviews how the immune system recognizes cancer, and the various escape mechanisms allowing tumour growth. The importance of the tumor microenvironment and the challenges this may present to achieving effective immunotherapy are discussed. Monoclonal antibodies, cellular, cytokine and vaccine therapies are all comprehensively reviewed, with particular focus on their potential application to pediatric cancers. Practical aspects of delivering such therapies to children, likely toxicities and potential biomarkers are considered. Finally, consideration is given to how, in the longer term, such therapies may be combined with conventional therapies such as chemotherapy and radiotherapy.
Edited by two distinguished pediatric oncologists with a collection of chapters from the most authoritative experts in cancer immunotherapy, this is an indispensable volume for pediatric oncologists and physicians working in childhood cancer care.
Table of Contents
Introduction to Pediatric Cancer Immunotherapy.- Overcoming immune suppression in the tumor microenvironment: Implications for multi-modal therapy.- Allogeneic stem cell transplantation.- Overview of monoclonal antibody therapies.- Monoclonal Antibodies Targeting Hematological Malignancies.- Monoclonal Antibodies Directly Targeting Antigens on Solid Tumours.- Monoclonal antibodies targeting the immune system.- Adoptive T Cell Therapies for Children’s Cancers.- NK Cell and NKT Cell Immunotherapy.- Cancer Vaccines in Pediatrics.- Immune Adjuvants and Cytokine Therapies.- Immune biomarkers in pediatric malignancies.- Future perspectives
