Capillary Electrophoresis : Trends and Developments in Pharmaceutical Research

著者名：Kanchi, Suvardhan (EDT)/Sagrado, Salvador (EDT)/Sabela, Myalo I. (EDT)/Bisetty, Krishna (EDT)

Jenny Stanford Publishing（2017/08/21発売）

• 言語：ENG
• ISBN：9789814774123
• eISBN：9781351846721

Description

Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.

 

Table of Contents

Capillary Electrophoresis: A Versatile Technique in Pharmaceutical Analysis

Imran Ali, Zeid A. Alothman, Abdulrahman Alwarthan, and Hassan Y. Aboul-Enein

Recent Applications of Chiral Capillary Electrophoresis in Pharmaceutical Analysis

José María Saz and María Luisa Marina

A Mini-Review on Enantiomeric Separation of Ofloxacin using Capillary Electrophoresis: Pharmaceutical Applications

Suvardhan Kanchi, Myalowenkosi Sabela, Deepali Sharma, and Krishna Bisetty

Nano-Stationary Phases for Capillary Electrophoresis Techniques

Chaudhery Mustansar Hussain and Sagar Roy

Capillary Electrophoresis Coupled to Mass Spectrometry for Enantiomeric Drugs Analysis

Vítězslav Maier, Martin Švidrnoch, and Jan Petr

Enantioselective Drug–Plasma Protein-Binding Studies by Capillary Electrophoresis

Laura Escuder-Gilabert, Yolanda Martín-Biosca, Salvador Sagrado, and María José Medina-Hernández

Clinical Use of Capillary Zone Electrophoresis: New Insights into Parkinson’s Disease

Pedro Rada, Luis Betancourt, Sergio Sacchettoni, Juan Félix del Corral, Hilarión Araujo, and Luis Hernández

Electrophoretically Mediated Microanalysis for Evaluation of Enantioselective Drug Metabolism

Yolanda Martín-Biosca, Laura Escuder-Gilabert, Salvador Sagrado, and María José Medina-Hernández

Capillary Electrophoresis for the Quality Control of Intact Therapeutic Monoclonal Antibodies

Anne-Lise Marie, Grégory Rouby, Emmanuel Jaccoulet, Claire Smadja, Nguyet Thuy Tran, and Myriam Taverna

Molecular Simulation of Chiral Selector–Enantiomer Interactions through Docking: Antimalarial Drugs as Case Study

Myalowenkosi Sabela, Suvardhan Kanchi, Deepali Sharma, and Krishna Bisetty