Translational Immunotherapy of Brain Tumors

著者名：Sampson, John H. (EDT)

Academic Press（2017/02/06発売）

• 言語：ENG
• ISBN：9780128024201
• eISBN：9780128026250

Description

Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors.Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike.2018 BMA Medical Book Awards Highly Commended in Oncology- Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas- Edited by a prominent neurosurgeon with contributions by leading researchers in the field- Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Table of Contents

Section I. Immunological Features of Brain Tumors1. An Introduction to Immunotherapy in the Treatment of Brain Tumors2. Immune Constitution of Patients With Brain Tumors3. The Role of Regulatory T Cells and Indoleamine-2,3-dioxygenase in Brain Tumor Immunosuppression4. The Role of Myeloid-Derived Suppressor Cells in Immunosuppression in Brain Tumors5. Tumor-Specific Mutations in Gliomas and Their Implications for ImmunotherapySection II. Studying Brain Tumor Immunotherapy6. Preclinical Immunotherapeutic Animal Models for Brain Tumors7. Imaging Studies in Immunotherapy8. Immunotherapy Clinical Trials in Neuro-OncologySection III. Experimental Brain Tumor Immunotherapies 9. Peptide-Specific Vaccines10. Immunotoxin Therapy for Brain Tumors11. Checkpoint Blockade Immunotherapy for Glioblastoma: Progress and Challenges12. Dendritic Cell Therapy for Brain Tumors13. Adoptive Immunotherapy Against Brain Tumors14. Chimeric Antigen Receptor Therapy of Brain Tumors