Description
Biology and Engineering of Stem Cell Niches covers a wide spectrum of research and current knowledge on embryonic and adult stem cell niches, focusing on the understanding of stem cell niche molecules and signaling mechanisms, including cell-cell/cell-matrix interactions.The book comprehensively reviews factors regulating stem cell behavior and the corresponding approaches for understanding the subsequent effect of providing the proper matrix molecules, mechanical cues, and/or chemical cues. It encompasses a variety of tools and techniques for developing biomaterials-based methods to model synthetic stem cell niches in vivo, or to enhance and direct stem cell fate in vitro.A final section of the book discusses stem cell niche bioengineering strategies and current advances in each tissue type.- Includes the importance of Cell-Cell and Cell Matrix Interactions in each specific tissue and system- Authored and edited by authorities in this emerging and multidisciplinary field- Includes valuable links to 5-10 minute YouTube© author videos that describe main points
Table of Contents
Part I. Biology of Stem Cell Niches and Molecular Mechanisms1. The Need to Study, Mimic, and Target Stem Cell Niches2. Harnessing the Biology of Stem Cells' Niche3. Pluripotent Stem Cell Microenvironment4. Regulation of Hematopoietic Stem Cell Dynamics by Molecular Niche Signaling5. HSC Niche: Regulation of Mobilization and Homing6. Neuronal Stem Cell Niches of the Brain7. Cardiovascular Stem Cell Niche8. Intestinal Epithelial Lgr5+ Stem Cell Niche and Organoids9. The Epithelial Stem Cell Niche in Skin10. The Satellite Cell Niche in Skeletal Muscle11. The Cancer Stem Cell Niche12. Cellular Senescence and Stem Cell NichePart II. Biochemical and Physical Cues in The Stem Cell Niche Directing Cell Fate13. Matrix Chemistry Controlling Stem Cell Behavior14. Matrix Growth Factor and Surface Ligand Presentation15. Effect of Matrix Mechanical Forces and Geometry on Stem Cell Behavior16. Wettability Effect on Stem Cell Behavior17. Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways18. Hypoxia Regulation of Stem Cell: Mechanisms, Biological Properties, and ApplicationsPart III. Designing Smart Biomaterials to Mimic and Control Stem Cell Niche19. Polymer Design and Development20. Design and Development of Ceramics and Glasses21. Surface Functionalization of Biomaterials22. Biofunctional Hydrogels for Three-Dimensional Stem Cell Culture23. Technologies to Engineer Cell Substrate Mechanics in Hydrogels24. Micro- and Nanosurface Patterning Technologies25. Self-Assembled Nanostructures (SANs)26. Biomimetic Nanofibers as Artificial Stem Cell NichePart IV. Bioengineering Strategies to Model Synthetic Stem Cell Niches27. Employing Microfluidic Devices to Induce Concentration Gradients28. Engineering Niches for Embryonic and Induced Pluripotent Stem Cells29. Engineering Niches for Cardiovascular Tissue Regeneration30. Engineering Niches for Blood Vessel Regeneration31. Engineering Niches for Bone Tissue Regeneration32. Engineering Vascular Niche for Bone Tissue Regeneration33. Engineering Niches for Cartilage Tissue Regeneration34. Engineering Niches for Stem and Progenitor Cell Differentiation Into Immune Cells35. Engineering Niches for Skin and Wound Healing36. Designing Stem Cell Niche for Liver Development and Regeneration37. Engineering the Niche for Intestinal Regeneration
