Mitochondrial Dysfunction in Neurodegenerative Disorders〈Second Edition 2016〉（2）

著者名：Reeve, Amy K. (EDT)/Simcox, Eve M. (EDT)/Duchen, Michael R. (EDT)/Turnbull, Doug M. (EDT)

Springer（2016/06/08発売）

• 言語：ENG
• ISBN：9783319286358
• eISBN：9783319286372

Description

This second edition brings together up-to-date contributionsfrom leaders in the field internationally on the various ways in whichmitochondrial dysfunction contributes to the pathogenesis of neurodegenerativediseases, including Parkinson’s disease, Alzheimer’s disease and multiplesclerosis. The reader is guided through the basic functions of mitochondria andthe mechanisms that lead to their dysfunction, and on to the consequences ofthis dysfunction for neuronal function before finishing with the modelling ofthese disorders and discussion of new potential therapeutic targets. 

Additional chapters have been added to the book to reflectadvances in the field and there are many new contributors and topics, includinghow mitochondria are degraded and the interaction of the mitochondria withpathologically relevant proteins. 

Mitochondrial Dysfunction in Neurodegenerative Disordersprovides an accessible, authoritative guide to this important area forneurologists; research and clinical neuroscientists; neuropathologists; andresidents with an interest in clinical research.

Table of Contents

Part I.Mitochondria and Neurodegenerative Disease.- An Introductionto Mitochondria, Their Structure and Functions.- Part II.Mitochondrial Dysfunction: Causes and Effects?.- Neurodegeneration in Mitochondrial Disorders.- The Ageing Brain,Mitochondria and Neurodegeneration.- Mitochondrial Genes and Neurodegenerative Disease.- MitochondrialSignalling and Neurodegeneration.- Part III. Functional Consequences ofMitochondrial Dysfunction.- Life on the Edge: Determinants of SelectiveNeuronal Vulnerability in Parkinson’s Disease.- MitochondrialDynamics and Neurodegeneration.- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation.-Mitochondria,the Synapse, and Neurodegeneration.- Protein Misfolding andAggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration.-Mitochondrial Degradation, Autophagy andNeurodegenerative Disease.- The DeleteriousDuo of Neurodegeneration: Lysosomes and Mitochondria.- PartIV. Measuring theContribution of Mitochondrial Dysfunction to Neurodegenerative Disease.- CanWe Accurately Model Mitochondrial Dysfunction in Neurodegeneration?.- MitochondrialFunction and Dynamics Imaged In Vivo.-Part V.  The Future.- Developmentof Treatments and Therapies to Target Mitochondrial Dysfunction.- Summary and Conclusions.