Description
This book, in Q&A format, addresses a wide range of clinically relevanttopics and issues in Nonmalignant Hematology, or “Benign Hematology,” with aview to offering a robust, engaging tool that will assist every hematologist andoncologist (pediatric and adult equally) in making decisions during day-to-daypractice. The entire spectrum of the specialty is covered in more than 60exceptional chapters written by acknowledged authorities in the field. Thecontent is organized into well-designed broad sections on red cell disorders,platelet and coagulation disorders, coagulopathy in systemic diseases,thromboembolic disease and its management (including surgical), immune systemand related disorders, hemostasis and thrombosis during pregnancy and in thenewborn and elderly, and Transfusion Medicine. A key aspect of the book is theopportunity it affords expert physicians to express well-reasoned opinionsregarding complex issues in Nonmalignant Hematology. Readers willfind that itprovides a practical and immediately applicable compendium of answers to oftencomplex and vexing questions. It will appeal to residents, fellows, houseofficers and more experienced practitioners around the globe.
Table of Contents
Part1. Red Blood Cells.- Evaluation of anemia in children and adults.- Iron cycle and pathophysiology of iron homeostasis.- Porphyrias: Diagnosis andmanagement.- Disorders of hemoglobin synthesis: Pathophysiology and diagnosticevaluation.- Management of thalassemias.- Allogeneic hematopoietic celltransplant in ß-thalassemia major.- Sickle cell disease: Prevention ofcomplications.- Sickle cell disease: Management of complications.- Allogeneichematopoietic cell transplant in sickle cell disease.- Anemia of inflammation.-Iron overload: Diagnosis, complications and management.- Megaloblastic andnutritional anemias.- Sideroblastic anemias: Diagnosis and management.- Primaryautoimmune warm antibody hemolytic anemias.- Intrinsic hemolytic anemias: Pathophysiology,diagnosis and management.- Part 2. Platelets and Coagulation System.- Plateletdisorders: Diagnostic tests and their interpretations.- Inherited plateletdisorders: Diagnosis and management.- Acquired platelet disorders: Diagnosisand management.- Immune mediated thrombocytopenia.- Coagulation cascade andfibrinolysis pathway: Assessment in the laboratory.- Abnormalities infibrinolysis pathway and clinical implications.- Congenital disorders offibrinogen: Clinical presentations, diagnosis and management.- Hemophilias Aand B: Diagnosis and management.- Coagulation factor inhibitors: Diagnosis andmanagement.- Rare coagulation factordeficiencies: Diagnosis and management.- von Willebrand disease: Differentialdiagnosis and diagnostic approach to specific subtypes.- von Willebranddisease: Prevention of complications and management of the disease.- Antifibrolytics:Indications and precautions.- Gene therapy for bleeding disorders.- Part 3. Coagulopathyin Systemic Diseases.- Disseminated intravascular coagulopathy.- Coagulopathyin critically ill subjects.- Trauma-associated coagulopathy.- Coagulationrelated issues in malignant hematology: Diagnosis and management.- Unmet clinicalneeds of antithrombotic treatment inBCR/ABL negative myeloproliferative neoplasms.- Bleeding andthrombosis in a cancer patient.- Management of surgical patient with thromboticand bleeding diathesis.- Part 3. Thrombosis and Therapeutics.- Prevention andtreatment of arterial thromboembolism.- mes New Roman","serif"">Prevention of venous thromboembolism.- Diagnostic,prognostic and therapeutic challenges in venous thromboembolisim.- Complicationsof venous thromboembolic disease.- Hereditarythrombophilias: Pathophysiology, timing of testing and familiar testing.- Anti-phospholipidantibodies and syndrome: Complexities in diagnosis and management.- Unidentifiablethrombophilias.- Anticoagulation drugs: Indications, therapeutic monitoring andantidotes.- Heparin induced thrombocytopenia: Diagnosis and management.- Thromboticthrombocytopenic purpura and hemolytic uremic syndrome.- Surgical treatment ofthromboembolic disease.- Part 4. Immune System and Related Disorders.- Nonmalignantleukocyte disorders.- Primary immunodeficiency disorders: Diagnosis andmanagement.- Disorders of phagocytic function:Diagnosis and treatment.- Inherited bone marrow failure syndromes.- Hemophagocytic lymphohistiocytosis: Diagnosisand management challenges.- Lysosomal storage disorders: Hematologyperspective.- Cryoglobulins andcryoglobulinemia.- Part 5. Hemostasis and Thrombosis in Pregnancy, Newbornand Elderly.- Reproductive issues in women with bleeding and thromboticdisorders.- Pregnancy in subjects withhemoglobinopathies: Precautions and management.- Neonatal thrombosis and coagulopathies.-Bleeding and thrombosis in elderly.- Part 6. Transfusion Medicine.- Transfusionsupport: Indications, efficacy and complications.- Human blood antigens andantibodies: Diagnostic and therapeutic implications.- Therapeutic apheresis inhematologic disorders: When and Why?
