Description
This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.
Table of Contents
Preface.- Multidrug resistance in cancer: a tale of ABC drug transporters.- Multidrug resistance: a role for membrane physics, pH and drug transporters.- Mechanisms and potential therapies for acquired resistance to inhibitors targeting the Raf or MEK kinases in cancer.- Mechanisms of resistance to targeted B-Raf therapies.- Role of β1integrins in the complication and drug resistance against lung cancer: targeting β1integrins to eradicate lung cancer.- Aldo-keto reductases as new therapeutic targets for colon cancer chemoresistance.- Overcoming drug resistance through elevation of ROS in cancer.- Cancer stem cells in resistance to cytotoxic drugs: implications in chemotherapy.- Two birds with a stone: molecular cancer therapy targeting signal transduction and DNA repair pathways.- Collateral sensitivity in drug-resistant tumor cells.- Human cancer resistance to trail-apoptotic pathway-targeted therapies.- The dark side of apoptosis.- Index.
