Description
This fourth edition of Huntington's Disease presents a comprehensive summary of the current knowledge of this disease, including the major scientific and clinical advances that have occurred since publication of the third edition in 2002.Completely updated and expanded, chapters in this volume are organized in five sections:· Clinical aspects of Huntington's disease, including updated chapters on historical perspectives, neurological, neuropsychiatric, and neuropsychological aspects, and new chapters on juvenile Huntington's and the premanifest and early stages· The genetics of Huntington's disease, including new information on its epidemiology discussions of new testing guidelines· Neurobiology, including recent insights into correlations between pathology and symptoms and a new chapter on neuronal circuitry· The molecular biology of Huntington's disease, including new chapters on the normal function of huntingtin, the molecular pathogenesis of Huntington's disease and the peripheral pathology of the disorder, and an extensively updated chapter on its structural biology· An updated description of the comprehensive care for Huntington's disease, featureing a new chapter on preclinical therapeutics and a completely rewritten chapter on the state of the art of experimental therapeutics and clinical trials.
Table of Contents
Table of ContentsSection 1: Clinical aspects of Huntington's disease1. Huntington's Disease in a Historical ContextPeter S Harper2. Clinical Neurology of Huntington's diseaseRaymund AC Roos3. Neuropsychiatry and NeuropsychologyDavid Craufurd and Julie Snowden4. Juvenile Huntington's diseaseOliver W J Quarrell5. Premanifest and Early Huntington's DiseaseEdward J Wild and Sarah J TabriziSection 2: The genetics of Huntington's disease6. Huntington's disease: genetic and molecular studiesCécile Cazeneuve and Alexandra Durr7. The Epidemiology of Huntington's DiseaseChris Kay, Emily Fisher, Michael R. Hayden8. Genetic Counselling and TestingRhona MacLeod and Aad TibbenSection 3: Neurobiology9. The Neuropathology of Huntington's Disease in the Human BrainHenry J Waldvogel, Eric H Kim, Lynette J Tippett, Jean-Paul G Vonsattel, and Richard LM Faull10. Altered Neuronal Circuitry in Huntington's DiseaseMichael S. Levine, Elizabeth A. Wang, Jane Y. Chen, Carlos Cepeda, and Véronique M. AndréSection 4: The molecular biology of Huntington's disease11. The normal function of huntingtinChiara Zuccato and Elena Cattaneo12. Order, disorder, and conformational flux in the structural biology of Huntington's DiseaseRonald Wetzel and Rakesh Mishra13. Pathogenic mechanisms in Huntington's diseaseAlis Hughes and Lesley Jones14. Peripheral pathology in Huntington's diseaseAuthors: Jorien M.M. van der Burg, N. Ahmad Aziz, Maria BjörkqvistSection 5: Therapeutic interventions in Huntington's disease15. Comprehensive care in Huntington's diseaseMartha A. Nance16. Preclinical Experimental Therapeutics in Huntington's DiseaseGillian P. Bates and Christian Landles17. Experimental Therapeutics in Huntington's Disease: Moving Forward in Clinical TrialsBeth Borowsky and Cristina Sampaio
