Description
Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40's-50's and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011).Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health.- Reveals the link between cardiac muscle disease and skeletal muscle disease- Explains how genetics and environmental factors effect muscle function of diverse origins- Designates current and novel therapeutic strategies that target both cardiac and skeletal muscle systems
Table of Contents
Section I. Physiology and Molecular Basis of MuscleChapter 1. Ventricular Systolic FunctionChapter 2. Basics of Skeletal Muscle Function and Normal PhysiologyChapter 3. Molecular Pathways in CardiomyopathiesChapter 4. Abnormal Muscle Pathology and PhysiologySection II. Diseases of Cardio-Skeletal PhenotypesChapter 5. Dilated Cardiomyopathy and Cardioskeletal InvolvementChapter 6. Hypertrophic CardiomyopathyChapter 7. Restrictive Cardiomyopathy Associated With Skeletal MyopathiesChapter 8. Left Ventricular Noncompaction CardiomyopathyChapter 9. Diseases of the Cytoskeleton: The DesminopathiesChapter 10. Diseases of Cardiac SarcomeresChapter 11. Diseases of the Intercalated DiscChapter 12. Diseases of the Nuclear MembraneSection III. Metabolic Causes of DiseaseChapter 13. Mitochondrial Disorders Causing Cardioskeletal Myopathies in ChildhoodChapter 14. Nonmitochondrial Metabolic Cardioskeletal MyopathiesSection IV. Syndromal and Chromosomal Causes of DiseaseChapter 15. Cardio-Skeletal Muscle Disease Associated With SyndromesChapter 16. Cardioskeletal Muscle Disease Associated With Chromosomal DisordersSection V. Cardio-Skeletal Myopathies Associated With Congenital Heart DiseaseChapter 17. Cardioskeletal Myopathies in Congenital Heart DiseasesSection VI. Future Directions in the Diagnosis and Management of Cardioskeletal Myopathic Disease in Children and Young AdultsChapter 18. Future Diagnostic Strategies—PediatricChapter 19. Neuromodulation of the Failing Heart
