Description
Viral Gastroenteritis: Molecular Epidemiology and Pathogenesis provides a comprehensive review of research on viruses causing acute gastroenteritis in infants and young children, including coverage of rotaviruses, human caliciviruses, astroviruses, enteric adenoviruses, and viruses causing gastroenteritis more rarely. Includes general chapters on gastrointestinal physiology and pathophysiology, gastrointestinal immune mechanisms, immunodeficiencies and host genetics influencing susceptibility to viral gastroenteritis, and therapeutic and preventative approaches.The book also includes special sections on virus particle structures, replication cycles, pathogenesis, immunology, epidemiology, and preventative measures. This book covers both basic science and translational applications and is an appropriate resource for virologists, molecular biologists, epidemiologists, gastroenterologists, vaccinologists, and those with an interest in public health.- Features new approaches in diagnosis and characterization of viral gastroenteritis pathogens- Includes coverage of therapeutic and preventative methods- Covers recent advances in characterizing the molecular biology and immune responses of rotaviruses and noroviruses- Covers both basic science and translational applications and is an appropriate resource for virologists, molecular biologists, epidemiologists, gastroenterologists, vaccinologists, and those with an interest in public health
Table of Contents
1. Gastrointestinal physiology and pathophysiology2. Gastrointestinal immunity3. Host genetics and susceptibility to gastrointestinal infections4. Immunodeficiencies, in particular IgA deficiency5. Metagenomics of viruses infecting the gut6. Gut microbiota and disease7. Therapy of gastroenteritis8. Rotavirus9. Structure function10. Replication (4-5 chapters)11. Pathogenesis (2 chapters)12. Immunology (2 chapters)13. Molecular epidemiology and evolution14. Vaccine and therapeutic developments and implementation (2 chapters) - Human caliciviruses - Structure function - Replication (2 chapters) - Animal models - Epidemiology and evolution (2 chapters) - Vaccine development - Astroviruses - Structure function - Replication (2 chapters) - Epidemiology - Other viruses causing gastroenteritis - Aichi virus - Enteroviruses - Picobirnavirus
