Description
This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders.- Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics- Identifies key concepts, methods, and findings- Includes coverage of multiple disorders from autism to schizophrenia- Reviews specific genes associated with disorders- Discusses the genetic architecture of these syndromes- Explains how recent findings are influencing the understanding of biology- Clarifies the promise of these findings for future treatment
Table of Contents
Section 1 The Genome Tools and Methods1. The Newly Emerging View of the GenomeStephan Sanders2. Genetic EpidmeiologyKathleen Ries Merikangas3. Common VariationMark Daly4. Rare/Structural VariationDaniel Barrera and Jonathan Sebat5. Epigenetics and EpigenomicsEric J. Nestler and John Greally6. BioinformaticsShaun Purcell7. Imaging GenomicsPaul Matthew Thompson8. Stem Cell Technology and GenomicsAlysson Renato Muotri9. Association StrategiesBenjamin M. Neale10. The promise of Systems BiologyEric Schadt11. Gene networks in neuropsychiatric diseaseDaniel Geschwind12. MosaicismChristopher A. Walsh and Saumya Shekhar JamuarSection 2 A new neuroanatomy13. Mapping the Molecular Landscape of the Human BrainNenad Sestan14. Studying CircuitsStephan Lammel and Robert Malenka15. Electrophysiological Measurement of CircuitsSrikantan S. Nagarajan16. Imaging the Circuitry of the Human BrainMichael Greicius17. Neuroimaging Advances in Alzheimer's DiseaseDaniel R. Schonhaut and Gil Rabinovici18. Progressive Supranuclear Palsy and Related Parkinsonian DisordersJesse A. Brown and William Seeley19. The Anatomy of Basal Ganglia Circuitry of BehaviorNicholas Au Yong, Adrienne M. Keener, Yvette Bordelon, Carlos Portera-Cailliau and Nader Pouratian20. Brainstem Circuitry of BehaviorHelmut Heisen21. Apathy – Basal Ganglia, Frontal CircuitsMario F. Mendez22. Emotion CircuitryRobert Wayne Levenson23. DelusionsGeorges Naasan24. HallucinationsDennis VelakoulisSection 3 Clinical Phenomenology25. Intro: Risk Overlap Among DisordersPatrick Sullivan26. The conundrum of Clinical Characterization RDOC/ICD-10/DSMBruce N. Cuthbert27. SchizophreniaAiden Corvin28. PsychosisRaquel E. Gur and Ruben Gur29. ASDRebecca Ann Muhle, Stephan Sanders, Hannah Reed and Matthew William State30. Bipolar DisorderNelson B. Freimer, Carrie E. Bearden and Peter Zandi31. MDDDavid C. Glahn32. Speech and Language DisordersMarilu Gorno-Tempini33. Molecular Pathways Leading to the Clinical Phenomenology of Frontotemporal DementiaSuzee Eurie Lee and Jennifer S. Yokoyama34. Alzheimer'sRudy Tanzi35. PTSDKerry Ressler36. Neurodevelopmental syndromesElliott Sherr37. EpilepsiesRyan S. Dhindsa, Daniel Lowenstein and David Goldstein38. Substance AbuseNii Addy39. NeuroimmunologyEmmanuel Mignot40. Brain TumorsVanessa Clark and Murat Günel41. White Matter DisordersMichael David Geschwind and Brianne Magouirk Bettcher42. ALSElena Ratti and James Berry43. Eating DisordersCynthia M. Bulik and Garret StuberSection 4 Clinical Translation and Drug Development44. PharmacogenomicsRoy H. Perlis
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