Description
Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.- Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring- Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring- Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference- Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window
Table of Contents
Overview of Therapeutic Drug MonitoringImmunoassays and Issues with Interference in Therapeutic Drug MonitoringApplication of Chromatography Combined with Mass Spectrometry in Therapeutic Drug MonitoringClinical Utility of Free Drug MonitoringTherapeutic Drug Monitoring of Newer Antiepileptic DrugsTherapeutic Drug Monitoring of AntiretroviralsTherapeutic Drug Monitoring in Infants and ChildrenTherapeutic Drug Monitoring in PregnancyTherapeutic Drug Monitoring in the ElderlyTherapeutic Drug Monitoring in Obese PatientsSpecial Issues in Therapeutic Drug Monitoring in Patients with Uremia, Liver Disease, and Critically Ill PatientsIntegrating Therapuetic Drug Monitoring and PharmacogenomicsWarfarin PharmacogenomicsDrug Monitoring in Alternative MatricesIntegrating and Supporting Therapeutic Drug Monitoring in a Hospital System
