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Description
Clinical Neuroendocrinology, Volume II discusses neuroendocrine science and its application to the analysis of human physiology and behavior. This book stresses the importance of the interrelationships between central and peripheral signals, neurotransmitters and neuromodulators, and target glands and peripheral tissues to ensure coordination of somatic and behavioral development and function. The ""centralist"" concepts of the importance of brain hormones are revised in this text, emphasizing that neurohumoral factors isolated from brain tissues, and initially considered to be primarily involved in the central nervous system regulation of the endocrine system, also exist outside the brain and spinal cord. This volume is valuable to neuroendocrinologists, but is also a good source for those involved in basic and clinical research and patient management.
Table of Contents
List of ContributorsPrefaceContents of Volume IChapter 1 Gonadai Hormones and Sexual Behavior I. Introduction II. Normal Physiology of Gonadai Steroids III. Phases of Sexual Life IV. Normal Sexual Differentiation V. Effect of Hormones on the Sexual Behavior of Animals VI. Control of Libido and Potentia VII. Sexual Identification in the Human VIII. Management of Patients with Ambiguous Genitalia IX. Conclusion ReferencesChapter 2 The Hypothalamic-Pituitary Unit: The Maturation of the Neuroendocrine System in the Fetus I. Introduction II. The Development of the Hypothalamic-Pituitary Unit III. The Regulation of Adenohypophyseal Function in the Fetus and Neonate IV. Concluding Comments ReferencesChapter 3 Neurotransmitter Control of Anterior Pituitary Hormone Secretion and Its Clinical Implications in Man I. Introduction II. Role of Catecholaminergic Neurotransmitters III. Role of Serotonin (5-HT) IV. Role of Acetylcholine V. Role of Histamine and 7-Aminobutyric Acid (GABA) VI. Role of Opioid Peptides VII. Clinical Significance of Neuropharmacological Mediation of Hypothalamic-Pituitary Relationships ReferencesChapter 4 Neuroendocrine Correlates of the Endorphins and Enkephalins I. Introduction II. Isolation and Identification of the Enkephalins and Endorphins III. Measurement of the Enkephalins and Endorphins IV. Distribution of Opiate Receptors and Endogenous Opiate Peptides V. Recent Concepts VI. Possible Physiological and Pathophysiological Roles of Endogenous Opiate Peptides VII. Conclusion—Future Outlook ReferencesChapter 5 Studies on Melatonin and Other Pineal Factors I. Introduction II. Pineal-Brain Interaction III. Human Pathology IV. Future Trends in Pineal Research ReferencesChapter 6 Endocrine Changes in Psychiatric Illness I. Introduction II. Depression III. Hypomania and Mania IV. Schizophrenia V. Anorexia Nervosa ReferencesChapter 7 Clinical Context, Neuroendocrine Relationships, and Nature of Inhibin in Males and Females I. History II. Demonstrations of the Existence of Inhibin III. Nature of Inhibin IV. Physiology of Inhibin V. The Modem Inhibin Hypothesis ReferencesChapter 8 Gut Hormones and the Brain I. Historical Notes II. Concepts III. Methods IV. Nomenclature V. Molecular Heterogeneity VI. The Peptides VII. The Brain-Visceral Axis VIII. Summary and Conclusions ReferencesChapter 9 Somatostatin and Its Physiology in Man in Health and Disease I. Introduction II. Isolation, Structure, and Synthesis of Somatostatin III. Actions of Exogenously Administered Somatostatin IV. Mechanism of Action of Somatostatin V. Measurement of Somatostatin VI. Metabolism of Somatostatin VII. Anatomical Localization of Somatostatin VIII. Molecular Heterogeneity of Somatostatin IX. The Physiological Role of Somatostatin X. Pathology of Somatostatin XI. Conclusions ReferencesChapter 10 Interspecies Study on the Distribution of Peptide Hormones Secreted by Neurons I. Introduction II. Hormones of the Hypothalamic-Neurohypophyseal System III. Luteinizing Hormone-Releasing Hormone IV. Somatostatin V. Thyrotropin-Releasing Hormone VI. Summary and Conclusions ReferencesIndex
