Central Actions of Angiotensin and Related Hormones

著者名：Buckley, Joseph P. (EDT)/Ferrario, Carlos M. (EDT)/Lokhandwala, Mustafa F. (EDT)

Pergamon（2013/10/22発売）

• 言語：ENG
• ISBN：9780080209333
• eISBN：9781483160436

Description

Central Actions of Angiotensin and Related Hormones investigates the centrally mediated actions of angiotensin and related hormones in the central nervous system (CNS). Topics covered include angiotensin I converting enzyme activity in the choroid plexus and in the retina; peptide regulation of neuronal excitability; effects of angiotensin-II and angiotensin-III on catecholamine biosynthesis; and humoral kidney mediation of adrenal catecholamine response to hemorrhage. A systems analysis of CNS-angiotensin interaction is also presented. This book is comprised of 51 chapters and opens with a discussion on the results of initial studies undertaken at the University of Pittsburgh to probe the centrally mediated hypertensive response of angiotensin II. The following chapters explore angiotensin receptor sites and angiotensin antagonists, along with the mechanisms involved in changes of blood pressure elicited by hypothalamic stimulation. The effects of angiotensin-II and angiotensin-III on the biosynthesis of catecholamines are also analyzed. The last chapter looks at recommendations regarding the nomenclature of the renin-angiotensin system, especially with respect to the extrarenal tissue enzymes. This monograph will be a valuable source of information for biochemists, biologists, physiologists, and pharmacologists.

Table of Contents

PrefaceList of ParticipantsInitial Studies on the Central Nervous System Effects of Angiotensin IIAngiotensin Receptor SitesAngiotensin AntagonistsAngiotensin I Converting Enzyme Activity in the Choroid Plexus and in the RetinaPeptide Regulation of Neuronal Excitability: Evidence for a Neurohormonal RoleMechanisms Involved in Changes of Blood Pressure Elicited by Hypothalamic StimulationRenin Substrate in the CNS: Potential Significance to Central Regulatory Mechanisms DiscussionOpen Discussion I Angiotensin and Sympathetic Activity Effects of Angiotensin-II and Angiotensin-III on Catecholamine Biosynthesis Humoral Kidney Mediation of Adrenal Catecholamine Response to Hemorrhage The Role of Efferent and Afferent Renal Nerves in the Release of Renin in the Cat Renal Adrenergic Effect of Angiotensin Discussion Physiologic Effects of the Renin-Angiotensin System on Sympathetic Nervous System Activity in the Conscious DogOpen Discussion II A Central Site of Action of Angiotensin II and Its Possible Role in the Central Regulation of the Cardiovascular System A Technique for Determining the Site of Action of Angiotensin and Other Hormones in the Brain Stem The Regulation of Vasomotor Centre Activity by Angiotensin DiscussionOpen Discussion III Systems Analysis of CNS/Angiotensin Interaction Direct and Centrally Mediated Cardiovascular Activity of Angiotensin III Interaction of Angiotensin II with Central Adrenergic Receptors Further Studies on Centrally Mediated Hemodynamic Effects of Angiotensin II in Anesthetized Cats Studies on the Interaction of Clonidine with the Hypertensive Activity of Angiotensin II Presence and Significance of Angiotensin in Cerebrospinal Fluid Immunopharmacology of Angiotensin I in Brain DiscussionOpen Discussion IV Hypothalamic Stimulation of ADH Release by Angiotensin II Interactions and Properties of Some Components of the Renin-Angiotensin System in Brain Inhibitors of the Renin-Angiotensin System in Rats with Malignant and Spontaneous Hypertension: Comparative Anti-Hypertensive Effects of Central vs.