Description
Platelets, Second Edition is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.- First edition won Best Book in Medical Science Award from the Association of American Publishers- Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias- A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references
Table of Contents
Part One: Platelet Biology 1. The Evolution of Mammalian Platelets 2. Megakaryocyte Development and Platelet Formation 3. Platelet Structure 4. The Platelet Cytoskeleton 5. Platelet Genomics and Proteomics 6. Platelet Receptors 7. The Glycoprotein Ib-IX-V Complex 8. Integrin αIIbβ3 9. Thrombin Receptors 10. The Platelet P2 Receptors 11. PECAM-1 12. P-Selectin/PSGL-1 and Other Interactions Between Platelets, Leukocytes, and Endothelium 13. Inhibition of Platelet Function by the Endothelium 14. Platelet Polymorphisms 15. Platelet Secretion 16. Signal Transduction During the Platelet Plug Formation 17. Outside-in Signaling By Integrin αIIbβ3 18. Platelet Thrombus Formation in Flowing Blood 19. Interactions Between Platelets and the Coagulation System 20. Platelet-Derived Microparticles 21. The Role of Platelets in Fibrinolysis 22. Platelet Function in the NewbornPart Two: Tests of Platelet Function 23. Clinical Tests of Platelet Function 24. Platelet Counting 25. The Bleeding Time 26. Platelet Aggregation 27. The VerifyNow System 28. Platelet Function Analyzer (PFA)-100 29. Impact Cone and Plate(let) Analyzer 30. Flow Cytometry 31. Thromboxane Generation 32. Perfusion Chambers 33. Animal Models 34. Real Time In Vivo Imaging of Platelets During Thrombus FormationPart Three: The Role of Platelets in Disease 35. Atherothrombosis and Coronary Artery Disease 36. Central Nervous System Ischemia 37. Peripheral Vascular Disease 38. Diabetes Mellitus 39. Inflammation 40. Antimicrobial Host Defense 41. Angiogenesis 42. Tumor Growth and Metastasis 43. Alzheimer's Disease 44. Psychiatric DisordersPart Four: Disorders of Platelet Number and Function 45. The Clinical Approach to Disorders of Platelet Number and Function 46. Immune Thrombocytopenic Purpura 47. HIV-1-related Thrombocytopenia 48. Heparin-induced Thrombocytopenia 49. Drug-induced Thrombocytopenia 50. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome 51. Thrombocytopenia in Pregnancy 52. Thrombocytopenia in the Newborn 53. Alloimmune Thrombocytopenia 54. Inherited Thrombocytopenias 55. Pseudothrombocytopenia 56. Thrombocytosis and Essential Thrombocythemia 57. Inherited Disorders of Platelet Function 58. Acquired Disorders of Platelet Function 59. Cardiopulmonary BypassPart Five: Pharmacology: Antiplatelet Therapy 60. Aspirin 61. ADP Receptor Antagonists 62. αIIbβ3 (GPIIb-IIIa) Antagonists 63. Dipyridamole 64. Cilostazol 65. Experimental Antiplatelet TherapyPart Six: Pharmacology: Therapy to Increase Platelet Numbers and/or Function 66. Platelet Growth Factors 67. Desmopressin (DDAVP) 68. Factor VIIaPart Seven: Platelet Transfusion Medicine 69. Platelet Storage and Transfusion 70. Platelet Substitutes and Novel Methods of Platelet PreservationPart Eight: Gene Therapy for Platelet Disorders 71. Gene Therapy for Platelet Disorders
