再生医療の基礎：臨床・治療への応用 Foundations of Regenerative Medicine : Clinical and Therapeutic Applications

著者名：Atala, Anthony (EDT)

Academic Press（2009/09/04発売）

• 言語：ENG
• ISBN：9780123750853
• eISBN：9780123785626

Description

The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today.Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field.- Highlights the fundamentals of regenerative medicine to relate to a variety of related science and technology fields- Introductory chapter directly addresses why regenerative medicine is important to a variety of researchers by providing practical examples and references to primary literature- Includes new discoveries from leading researchers on restoration of diseased tissues and organs

Table of Contents

PrefaceI. INTRODUCTION TO REGENERATIVE MEDICINECurrent and Future Perspectives of Regenerative medicineFundamentals of cell-based therapiesStem Cell ResearchII. BIOLOGIC AND MOLECULAR BASIS FOR REGENERATIVE MEDICINEMolecular Organization of CellsCell-ECM interactions In Repair and RegenerationDevelopmental Mechanisms of RegenerationThe molecular basis of pluripotency in Principles of Regenerative MedicineIII. CELLS AND TISSUE DEVELOPMENT Embryonic Stem Cells: Derivation and PropertiesStem cells derived from amniotic fluid and placentaBone Marrow stem cells: Properties and PluripotencyMesenchymal Stem cellsIslet Cell Therapy and Pancreatic Stem CellsMechanical Determinants of Tissue Development Morphogenesis and Morphogenic Proteins Physical stress as a factor in tissue growth and remodelingEngineering Cellular MicroenvironmentsApplications of NanotechnologyIV. BIOMATERIALS FOR REGENERATIVE MEDICINEDesign Principles in Biomaterials and ScaffoldsNaturally Occurring Scaffold MaterialsSynthetic PolymersSurface Modification of BiomaterialsBiocompatibility and Bioresponse to biomaterialsV. THERAPEUTIC APPLICATIONS: Cell TherapyClinical islet transplantationCell Based Repair for Cardiovascular Regeneration and NeovascularizationCell therapies for bone regenerationCell-Based Therapies for Musculoskeletal RepairHepatocyte TransplantationCell Based Drug DeliveryVI. THERAPEUTIC APPLICATIONS: Tissue TherapyEngineering of Large Diameter VesselsCardiac TissueIntracorporeal Kidney Support Genitourinary SystemTissue Engineering of the Reproductive SystemPhalanges and Small JointsFunctional Tissue Engineering of Ligament and Tendon InjuriesSkeletal MusclePeripheral Nervous SystemInnovative Regenerative Medicine Approaches to Skin Cell Based Therapy for Patients With Burn InjuriesVII. REGULATION AND ETHICSEthical ConsiderationsTo Make Is to Know: The Ethical Issues in Human Tissue EngineeringOverview of FDA Regulatory ProcessCurrent Issues in US Patent Law