Microsomes and Drug Oxidations : Proceedings of the Third International Symposium, Berlin, July 1976

著者名：Ullrich, Volker (EDT)/Hildebrandt, Alfred (EDT)/Roots, Ivar (EDT)

Pergamon（2013/10/22発売）

• 言語：ENG
• ISBN：9780080215235
• eISBN：9781483159089

Description

Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.

Table of Contents

ContentsList of ParticipantsPrefaceOtto Rosenthal, the Man and His WorkI BiochemistryLipid Structure of Liver Microsomal Membranes, Limitations of a ModelA Study of Cytochrome P-450 Reduction by Sodium Dithionite Investigation of Microsomal Hydroxylating System at Sub-Zero TemperaturesIsolation of Microsomal Electron Transport Components and Reconstitution of the Electron Transfer Activity on Liposomal VesiclesDifferences in Substrate Affinity and Catalytic Specificity of Inducible and Non-Inducible Forms of Cytochrome P-450 in Rabbit LiverEffects of Buffer Composition on the Low-Spin ESR Spectrum of Cytochrome P-450Kinetics of TiamutinR Interaction with Cytochrome P-450 from Rabbit LiverDifferent Phases of Hydroxylase Induction in Liver Microsomes of Female Mice during Inhalation of Cyclohexane and D,L-CamphorProtein-Lipid Interactions in the Liver Microsomal Hydroxylase SystemFurther Studies of the Fluroxene Mediated Destruction of Hepatic Microsomal Cytochromes P-450 in VitroPurification of Membrane-Bound Oxygenases: Isolation of two Electrophoretically Homogeneous Forms of Liver Microsomal Cytochrome P-450Microsomal Hemeproteins P-450LM-2 and P-450LM4 : Comparative Structural StudiesHepatic Microsomal Ethanol Oxidizing System: Isolation and ReconstitutionCharacterization of NADPH-Cytochrome c (P-450) Reductase Purified by Biospecific Affinity Chromatography Utilizing Spectrophotometric and Electron Paramegnetic Resonance TechniquesRelationship between the Membrane Lipids and Substrate-Cytochrome P-450 Binding Reaction in Bovine Adreno-Cortical MicrosomesKinetic and Spectral Evidence for Multiple Species of Cytochrome P-450 in Liver MicrosomesDifferences in the Interactions of R and S Warfarin with Hepatic Microsomal Cytochrome P-450Multiple Forms of Housefly Cytochrome P-450 Catalytic Hydroxylation Activities and Some Other Properties of Partially Purified Rabbit Pulmonary Microsomal Cytochrome P-450Hepatic Microsomal and Solubilized Mixed-Function Oxidase Systems from the Little Skate, Raja erinaoea, A Marine ElasmobranchAminimide Polymers as Supports for Affinity Chromatography, Under Low and High Pressure, of Microsomal EnzymesSex Differences in the Pattern of Cytochromes P-450 in Rat Liver MicrosomesCharacterization of Multiple Forms of Highly Purified Cytochrome P-450 from the Liver Microsomes of Rats, Mice and RabbitsThe Mechanism of Cytochrome P-450 Action Oxygen Reactions of the P-450 Heme Protein The Peroxidase Nature of Cytochrome P-450Cytochrome P-450 Catalyzed Oxene Transfer from Various DonorsAssociation of Type I, Type II, and Reverse Type I Difference Spectra with Absolute Spin State of Cytochrome P-450 IronNMR Relaxation Time Studies of Substrate Interactions with P-450 and other HemoproteinsThe Interaction of Polyhalogenated Methanes with Ferrous Cytochrome P-450Substrate-Elicited Dissociation of the Isosafrole Metabolite-Cytochrome P-450 Complex and the Consequential Reactivation of MonooxygenationThe Interaction of Halothane with Liver Microsomal Cytochrome P-450The Formation of Hydrogen Peroxide During Hepatic Microsomal Electron Transport ReactionsOxygen Transfer in Microsomal Oxidative Desulfuration Redox and Ligand Dynamics in P~450cam - Putidaredoxin ComplexesThe Inhibition of Mixed-Function Oxidation Reactions by Amphetamines in Liver and Lung MicrosomesThe Physiological Implications of Drug Oxidations to the CellNicotinamide Nucleotide Systems and Drug Oxidation in the Liver CellThe Role of Reducing Equivalents Generated in Mitochondria in Hepatic Mixed-Function OxidationDestruction of Cytochrome P-450 by Linoleic Acid HydroperoxideStoichiometry of Oxygen Uptake, NADPH Oxidation and Ethylmorphine N-Demethylation by Hepatic MicrosomesStructural and Functional Interaction of Rough Endoplasmic Reticulum (RER) and Mitochondria during Synthesis of Hepatic Cytochrome P-450Mechanism of N-Oxide Formation by Hepatic Mixed Function OxidasesA Preliminary Comparati