Advances in Radiation Biology : Volume 7

著者名：Lett, John T. (EDT)/Adler, Howard (EDT)

Academic Press（2013/10/22発売）

• 言語：ENG
• ISBN：9780120354078
• eISBN：9781483281919

Description

Advances in Radiation Biology, Volume 7, provides an overview of the state of knowledge in the field of radiation biology. The book contains six chapters and opens with a study on the exploitation of the unique properties of purified lesion-recognizing enzymes as the basis of assays that monitor the repair of DNA lesions in vivo. This is followed by separate chapters on the effects of radiation on living eukaryotic cells; the ecological effects of ionizing radiation; and the applicability of bacterial models of DNA repair and recovery to UV-irradiated mammalian cells. Subsequent chapters focus on acute radiation effects on the adult nervous system and the repair of DNA modified by cytotoxic, mutagenic, and carcinogenic chemicals.

Table of Contents

ContributorsPrefaceContents of Other VolumesUse of Purified Lesion-Recognizing Enzymes to Monitor DNA Repair in Vivo I. Introduction II. Enzymatic Repair Mechanisms III. Conventional Repair Assays IV. Enzymatic Assays V. Experimental Applications of Enzymatic Assays VI. Compendium of Lesion-Specific Endonucleases VII. Concluding Comments and Perspectives Note Added in Proof ReferencesThe Crucial Role of DNA Double-Strand Breaks in Cellular Radiobiological Effects I. Introduction II. The Basis of the Molecular Theory III. Cell Survival IV. Chromosomal Aberrations V. Somatic Mutations VI. Radiation-Induced Malignancy VII. Hereditary Effects VIII. Summary and Conclusions ReferencesEvaluating the Effects of Ionizing Radiation on Aquatic Organisms I. Introduction II. Dosimetry in the Aquatic Environment III. Effects of Ionizing Radiation on Aquatic Invertebrates IV. Effects of High-Level Radiation Exposure on Adult Fish V. Effects of Acute Irradiation on Teleosts VI. Effects of Irradiation on Developing Fish Eggs VII. Cytological and Genetic Effects of Irradiation on Aquatic Organisms VIII. Effects of Radiation on Natural Populations XI. Discussion ReferencesApplicability of Bacterial Models of DNA Repair and Recovery to UV-Irradiated Mammalian Cells I. Objective of Review II. Repair and Recovery in Bacteria III. Excision Repair in Mammalian Cells IV. DNA Synthesis and Replication V. Postreplication Repair VI. Summary and Conclusions ReferencesElectrophysiological Studies on Radiation-Induced Changes in the Adult Nervous System I. Introduction II. Physiological Changes in the Nervous System Induced by Ionizing Radiation ReferencesThe Repair of DNA Modified by Cytotoxic, Mutagenic, and Carcinogenic Chemicals Part A. Chemical Modifications to DNA and Their Cytotoxic, Mutagenic, and Carcinogenic Consequences I. Introduction II. Reactions of Chemicals with Nucleic Acids III. Biological Effects of Reactions with DNA Part B. Repair of Chemically Modified DNA I. Excision Repair II. Postreplication Repair III. Genetic Factors and DNA Repair Part C. Conclusions and Perspectives List of Abbreviations ReferencesSubject Index