Ｂ細胞の分子生物学（第２版） Molecular Biology of B Cells（2）

著者名：Honjo, Tasuku (EDT)/Reth, Michael (EDT)/Radbruch, Andreas (EDT)/Alt, Frederick (EDT)

Academic Press（2014/10/09発売）

• 言語：ENG
• ISBN：9780123979339
• eISBN：9780123984906

Description

Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes.Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality.  The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application.  With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.- Covers signaling mechanisms regulating B cell differentiation- Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab- Contains studies on B cell tumors from various stages of B lymphocytes- Offers an integrated view of all aspects of B cells to produce a normal immune response

Table of Contents

1. Ig loci: structure and expression regulation2. The mechanisms of V(D)J recombination3. Transcriptional regulation of B lymphocyte differentiation4. B cell transcriptome5. The role of microRNA in B cell development and function6. Proliferation and differentiation program of developing B cells7. Development and function of B cell subsets8. Evolution of primordial B cell antigen receptor9. The evolutionary origin of V(D)J diversification10. Receptor organization on B cells and its signaling11. Fc and complement responses12. The dynamic structure of germinal center: generation of high affinity Ab13. Cell Migration14. B cell as regulator15. B cell memory and plasma cell development16. Roles of lymphotoxin and Baff on B cells17. The mucosal immune system: host-bacteria interaction and regulation of IgA synthesis18. Gut microbiota and their regulation19. Regulation and function of activation-induced cytidine deaminase20. Molecular mechanism of CSR21. Molecular mechanism of SHM22. Aberrant AID expression by pathogen infection23. Chromosomal translocation and mutations in B cell leukemia and lymphomas24. B cells producing pathogenic autoantibodies25. HIV neutralizing Ab26. Immune deficiency caused by B cell defects27. IMGT® for immunoglobulin repertoire analysis and antibody humanization28. Humanized monoclonal Ab production29. Ab therapy against lymphoma30. Anti-interleukin-6 receptor antibody therapy against autoimmune inflammatory diseases31. Ab therapy against chronic inflammatory immune-mediated diseases