Description
Platelets - winner of a 2013 Highly Commended BMA Medical Book Award for Internal Medicine - is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource.- Highly Commended BMA Medical Book Award 2013: Internal Medicine- Comprehensive and definitive source of knowledge about platelets for clinicians, pathologists and scientists- Integrates the entire field of platelet biology, pathophysiology, and clinical medicine- Full color reference comprising 64 chapters, 1400 pages, and 16,000 references- Contributions from 126 world leaders in their fields- New chapters on topics such as the regulation of platelet life span, platelet microRNAs, GPVI and CLEC-2, monitoring of antiplatelet therapy, novel antiplatelet therapy, and making platelets ex vivo
Table of Contents
ForewordA Brief History of Ideas About Platelets in Health and DiseasePart One: Platelet Biology1. The Evolution of Mammalian Platelets2. Megakaryocyte Development and Platelet Formation3. The regulation of platelet life span4. Platelet Genomics 5. Platelet MicroRNAs6. The Platelet Proteome 7. Platelet Structure8. The Platelet Cytoskeleton9. Platelet Receptors 10. The GPIb-IX-V Complex 11. GPVI and CLEC-212. Integrin AlphaIIb Beta3 13. Protease-activated Receptors 14. The Platelet P2 Receptors15. PECAM-116. Interactions Between Platelets, Leukocytes and the Endothelium17. Inhibition of Platelet Function by the Endothelium18. Platelet Secretion19. Signal Transduction During Platelet Plug Formation20. Platelet Thrombus Formation in Flowing Blood21. Interactions Between Platelets and the Coagulation System 22. Platelet-Derived Microparticles23. The Role of Platelets in Fibrinolysis24. The Role of Platelets in Angiogenesis 25. Platelet Function in the NewbornPart Two: Tests of Platelet Function26. Clinical Tests of Platelet Function27. Platelet Counting28. Platelet Aggregation29. Flow Cytometry30. Monitoring of Antiplatelet Therapy31. Real Time In Vivo Imaging of Platelets During Thrombus FormationPart Three: The Role of Platelets in Disease32. Atherothrombosis and Coronary Artery Disease 33. Central Nervous System Ischemia 34. Peripheral Vascular Disease35. Diabetes Mellitus36. Inflammation 37. Antimicrobial Host Defense38. Tumor Growth and MetastasisPart Four: Disorders of Platelet Number and Function39. The Clinical Approach to Disorders of Platelet Number and Function 40. Immune Thrombocytopenia (ITP)41. Drug-induced Thrombocytopenia42. Heparin-induced Thrombocytopenia 43. Thrombotic Thrombocytopenic Purpura and the Hemolytic-Uremic Syndrome44. Thrombocytopenia in Pregnancy45. Thrombocytopenia in the Newborn46. Alloimmune Thrombocytopenia47. Inherited Thrombocytopenias 48. Pseudothrombocytopenia 49. Thrombocytosis and Essential Thrombocythemia50. Congenital Disorders of Platelet Function 51. Acquired Disorders of Platelet Function52. Cardiopulmonary BypassPart Five: Antiplatelet Therapy53. Aspirin 54. ADP Receptor Antagonists 55. AlphaIIb Beta3 (GPIIb-IIIa) Antagonists56. Dipyridamole57. Cilostazol58. Novel Antiplatelet TherapiesPart Six: Therapy to Increase Platelet Numbers and/or Function59. Thrombopoietin Mimetics 60. Desmopressin61. Factor VIIa62. Platelet Transfusion Medicine63. Making Platelets Ex Vivo 64. Gene Therapy for Platelet Disorders
