Immunological Tolerance : Mechanisms and Potential Therapeutic Applications

著者名：Katz, David H. (EDT)/Benacerraf, Baruj (EDT)

Academic Press（2014/06/28発売）

• 言語：ENG
• ISBN：9780124016507
• eISBN：9781483273433

Description

Immunological Tolerance: Mechanisms and Potential Therapeutic Applications documents the proceedings of a conference held at Brook Lodge, Michigan, April 27-May 1, 1974. The conference brought together many of the investigators who have actively contributed to furthering knowledge and understanding of immunological tolerance. It will be immediately clear to the reader that the conference was structured in a way to consider phenomena of tolerance and immune suppression as interrelated entities with a certain degree of emphasis on the possible common cellular mechanisms involved. The volume contains 36 contributions presented during the seven sessions of the conference. The papers presented in Session I examined T-cell tolerance. The presentations in Session II focused on B cell tolerance. The papers in Sessions III and IV focused on the mechanisms of B cell and T cell tolerance, respectively. Session V dealt with the activity of suppressor cells as a mechanism of tolerance. The papers in Session VI investigated the suppressive activity of antibody and antigen-antibody complexes. In Session VII a final General Discussion was held in order to identify what has been established concerning the phenomenology and mechanisms of specific immunological tolerance, what are the major unresolved issues, and what approaches appear most promising to answer these questions.

Table of Contents

ParticipantsPrefacePhotographs of ParticipantsSession I: T Cell Tolerance Factors Influencing the Rate of Induction of Tolerance by Bovine Gamma Globulin Discussion following David Dresser Interactions of T and B Lymphocytes in Self-Tolerance and Autoimmunity Discussion following Anthony Allison The Cellular Basis for Establishing Tolerance or Immunity to Bovine γ-Globulin in Mice The Role of Accessory and Thymus-Derived Cells in Resistance to Tolerance Induction Suppressor Activity in Mice Tolerant of Hemocyanin Specific Suppression of the Immune Response by T Cells Tolerance to Contact Sensitivity—a Role for Suppressor T Cells? General Discussion—Session ISession II: B Cell Tolerance Activation of and Tolerance Induction in DNP-Specific B Cells: Analysis with Three Distinct DNP-Carrier Conjugates Discussion following William E. Paul Three Catergories of B Cell Tolerance Induced by Polysaccharides: Characteristics, Interrelationships and General Implications Discussion following James Howard Effect of Tolerance on Antibody-Binding Affinity Hapten-Specific Tolerance Induced by the DNP Derivative of D-Glutamic Acid and D-Lysine (D-GL) Copolymer Tolerance in Isolated B-Cell Populations Identified by an Allotype Marker: Role of T Cells in Induction B Cell Tolerance Induced by Non-Metabolized or Toxic Antigens Effect of Epitope Density on the Induction of Tolerance In Vitro General Discussion—Session IISession III: Mechanisms of B Cell Tolerance Reversible and Irreversible B Cell Tolerance: Distinguishing Properties and Mechanisms Discussion following David H. Katz High-Dose Tolerance in Mice Deficient in Reactive T Cells Discussion following Graham F. Mitchell Functional Relationships in Antigen-Receptor Interactions in B Lymphocytes B Cell Tolerance In Vitro—the Fate of the Tolerant Cell and Its Control by Hormones Graft-versus-Host Reactions, Tumor-Specific Immunity and Self-Tolerance Receptor Blockade by Tolerogen: One Explanation of Tolerance General Discussion—Session IIISession IV: Mechanisms of T Cell Tolerance Unifying Concepts in Tolerance Induction for Various T and B Cell Sub-Populations Discussion following G.J.V. Nossal Cellular Parameters of the Tolerant State Induced to Human γ Globulin in Mice and of Its Modulation by Bacterial Lipopolysaccharides Discussion following Jacques M. Chiller Effect of Antigen Structure on the Induction of Tolerance in T Cells Indications of Active Suppression in Mouse Carriers of Lymphocytic Choriomeningitis Virus Interactions between T Cells Which Result in Suppression of T Cell Functions General Discussion—Session IVSession V: Activity of Suppressor Cells as a Mechanism of Tolerance Introduction Lack of Activity of Contra-Suppressor T Cells as a Mechanism of Tolerance Discussion following Richard K.