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Description
The Antibody Molecule reviews the literature leading to current knowledge of the structure of immunoglobulins. The book begins by outlining some of the basic structural characteristics of immunoglobulins without citing the references on which the information is based. Separate chapters follow covering the chemical nature of the active site of an antibody molecule and mechanisms of interaction with hapten; the general structural features and properties of the various classes of human immunoglobulin; and amino acid sequences of human and mouse L chains and of human and rabbit H chains. Subsequent chapters deal with the evolution of the immunoglobulin classes; special properties of mouse, guinea pig, rabbit, and horse immunoglobulins; idiotypic specificities of immunglobulins; and the genetic control of antibodies. This book is meant for immunologists who have not personally observed the development of this exciting period in the history of immunology. It will also provide useful supplemental reading for the serious student or investigator who wishes to become familiar with the nature of the antibody molecule, its genetic control, and mode of action.
Table of Contents
Preface1 General Structural Features of Immunoglobulin Molecules; Myeloma Proteins Myeloma and Bence Jones Proteins Nomenclature References2 Nature of the Active Site of an Antibody Molecule and the Mechanism of Antibody-Hapten Interactions I. Inhibition of Precipitation by Haptens and Chemical Modification as Probes for Antibody Specificity II. Specificity of Antibodies to Synthetic Polypeptides III. Stabilization of the Antibody Molecule by Interaction with Hapten IV. Induction of Optical Activity in Hapten Bound to Antibody V. The Question of Conformational Changes Induced in Antibodies upon Interaction with Antigen or Hapten VI. Rates and Energetic Aspects of Antigen-Antibody Reactions VII. Affinity Labeling of Antibody Molecules or Myeloma Proteins with Antibody Activity References3 Human Immunoglobulins I. General Structural Properties II. Kappa and Lambda Chains III. IgG and Its Subclasses IV. Structure and Properties of Human IgM V. Structure and Properties of Human IgA VI. IgE VII. IgD VIII. ß2-Microglobulin (ß2m) IX. Rheumatoid Factors References4 Amino Acid Sequences in Human Immunoglobulins and in Mouse Light Chains I. Introduction II. Numbering System III. Amino Acid Sequences in Human L Chains IV. Amino Acid Sequences in L Chains of the Mouse V. Common Evolutionary Origin of K and A Chains of Human and Mouse Origin VI. Amino Acid Sequences in Rabbit K Chains VII. Amino Acid Sequences in Human and Rabbit H Chains VIII. Amino Acid Sequence of ß2-Microglobulin IX. Amyloidosis X. Carbohydrate in Immunoglobulins References5 The Three-Dimensional Structure of Immunoglobulins I. X-Ray Crystallography II. Physicochemical Investigations Relating to Three-Dimensional Structure References6 Properties and Interactions of the Light and Heavy Chains of Immunoglobulins I. Introduction II. Separation of Light and Heavy Chains III. Solubility and Conformational Properties of the Isolated Chains IV. Antibody Activity in Isolated Chains and in Recombinants of Heavy and Light Chains V. Interaction of VL or CL Segments of Light Chains with Intact Heavy Chains VI. Stability of Fragments Consisting Only of V Domains VII. Effect of Hapten on the Strength of Interaction of H and L Chains VIII. Contribution to Antibody Activity of Isolated H and L Chains IX. Half-Molecules of IgG References7 Evolution of the Immunoglobulins I. Introduction II. Universality of IgM-Like Molecules in Vertebrates III. Immunoglobulins of Fish IV. Immunoglobulins of Amphibia V. Immunoglobulins of Reptiles VI. Immunoglobulins of Birds; Appearance of IgA VII. Carbohydrate Content of Immunoglobulins from Various Species on the Phylogenetic Scale VIII. Phylogeny of IgA, IgE, IgG Subclasses, Light Chain Types, and the VHm Subgroup IX. Selective Advantages in the Evolution of Immunoglobulin Classes References8 Immunoglobulins of the Rabbit, Mouse, Guinea Pig, and Horse I. Introduction II. General Considerations III. Antigeiiic Relationships IV. Homocy to tropic Antibodies: IgE V. Rabbit Immunoglobulins VI. Guinea Pig Immunoglobulins VII. Mouse Immunoglobulins VIII. Horse Immunoglobulins IX. Passive Cutaneous Anaphylactic Reactions in Guinea Pigs Mediated by Heterologous Immunoglobulins References9 Allotypes of Rabbit, Human, and Mouse Immunoglobulins I. Introduction II. Rabbit Allotypes III. Human Allotypes IV. Mouse Allotypes V. Suppression of Allotypic Specificities References10 Homogeneous Antibodies and Myeloma Proteins with Antibody Activity I. Introduction II. Homogeneous Antistreptococcal Antibodies III. Homogeneous Antibodies to Pneumococcal Polysaccharides IV. Homogeneous Antihapten Antibodies V.
