Description
This book describes the major achievements and discoveries relevant to bacterial protein toxins since the turn of the new century illustrated by the discovery of more than fifty novel toxins (many of them identified through genome screening). The establishment of the three-dimensional crystal structure of more than 20 toxins during the same period offers deeper knowledge of structure-activity relationships and provides a framework to understand how toxins recognize receptors, penetrate membranes and interact with and modify intracellular substrates.- Edited by two of the most highly regarded experts in the field from the Institut Pasteur, France- 14 brand new chapters dedicated to coverage of historical and general aspects of toxinology- Includes the major toxins of both basic and clinical interest are described in depth- Details applied aspects of toxins such as therapy, vaccinology, and toolkits in cell biology- Evolutionary and functional aspects of bacterial toxins evaluated and summarized- Toxin applications in cell biology presented- Therapy (cancer therapy, dystonias) discussed- Vaccines (native and genetically engineered vaccines) featured- Toxins discussed as biological weapons, comprising chapters on anthrax, diphtheria, ricin etc.
Table of Contents
IntroductionA 116-year story of bacterial protein toxins (1888-2004): From 'diphtheritic poison' to molecular toxinologyEvolutionary aspects of toxin-producing bacteriaMobile genetic elements and pathogenicity islands encoding bacterial toxinsRegulation systems of toxin expressionToxin secretion systemsIntracellular trafficking of bacterial protein toxinsTranslocation of bacterial protein toxin into the cytosolBacterial toxins and virulence factors targeting the actin cytoskeleton and intracellular junctionsBacterial toxins and mitochondriaToxins activating RHO GTPases and exploiting the cellular ubiquitin/proteasome machineriesToxin receptorsMolecular, functional and evolutionary aspects of ADP-ribosylating toxinsDiphtheria toxinAttack of the nervous system by clostridial toxins: Physical findings, cellular and molecular actionsUptake and transport of clostridial neurotoxinsBacillus anthracis toxinsLarge clostridial cytotoxins modifying small GTPasesBordetella protein toxinsVibrio Cholerae and Escherichia Coli thermolabile enterotoxinThe Shiga toxins: Properties and action on cellsHelicobacter pylori vacuolating toxinPasteurella multocida toxinCytolethal distending toxinsPseudomonas aeruginosa toxinsEscherichia coli heat- stable enterotoxin bParadigms and classification of bacterial membrane -damaging toxinsMembrane damaging and cytotoxic phospholipasesBacteroides fragilis toxinsStructure and mode of action of RTX cytolysinsGenetics and phylogeny of RTX cytolysinsThe family of two-component cytolysins of Serratia and other bacteriaAlpha-helix and Beta-barrel pore-forming toxins (leucocidins, alpha-, gamma- and delta-cytolysins) of Staphylococcus aureusAerolysin and related Aeromonas toxinsClostridium septicum pore-forming alpha-toxinClostridium perfringens epsilon toxinRepertoire and general features of the family of cholesterol–dependent cytolysinsComparative three-dimensional structure of cholesterol-dependent cytolysinsPerfringolysin O and Intermedilysin: mechanisms of pore formation by the cholesterol-dependent cytolysinsPneumolysin: structure, function and role in diseaseListeriolysinEnterococcus faecalis cytolysin toxinStreptolysin S: one of the most potent and elusive of all bacterial toxinsThe group B streptococcal beta-haemolysin/cytolysinHaemolysins of Vibrio cholerae and other Vibrio speciesClostridium perfringens enterotoxinBacillus cereus enterotoxins, bi- and tri-component cytolysins and other haemolysinsUropathogenic Escherichia coli cytolysinsEscherichia coli, Vibrio and Yersinia species heat-stable enterotoxinsWhat are superantigens ?Staphylococcal superantigens and the diseases they causeStreptococcal superantigenic toxinsSuperantigenic toxin of Yersinia pseudotuberculosisComparative three-dimensional structure of bacterial superantigenic toxinsInduction and modulation of inflammatory networks by bacterial protein toxinsClostridial toxins in the pathogenesis of gas gangreneStaphylococcal exfoliative toxinsMedical applications of botulinum neurotoxinsBacterial protein toxins as food poisons Engineering of bacterial toxins for research and medicineEngineered bacterial toxin vaccines and adjuvantsToxins as toolsBacterial protein toxins as biological weaponsINDEX
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