Description
The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.Key Features* Covers all main cytokines and chemokines * Written by experts* Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters* Includes major emphasis on clinical applications* Extensively illustrated with tables and figures
Table of Contents
Volume 1PrefaceForewardSection I Basic Cytokine Biology1Cytokines Overview2Cytokine Genetics3The Phylogeny of Cytokines4Cytokine SignallingSection II The Cytokines and ChemokinesSubsection A. The Hematopoietin Family Members5Growth Hormone and its Receptors6Prolactin7Erythropoietin8Interleukin 29Interleukin 310Interleukin 411Interleukin 512Interleukin 613Interleukin 714Interleukin 915Interleukin 1116Interleukin 12 Family: IL-12 17Interleukin 1318Interleukin 15 and Interleukin 2119Interleukin 1620Interleukin 1721Granulocyte-Macrophage 22Granulocyte Colony-Stimulating Factor and its Receptor 23M-CSF Subsection B. The Interferon Family Members24Type I Interferons25Interferon-g26Interleukin 1027Interleukins 19, 20, 22, 24 and 26 Volume II. Subsection C. The beta trefoil cytokines28Interleukin 1 a and b29Interleukin 1 Receptor Antagonist30Novel Interleukin-1 Homologues31Interleukin 1832The Fibroblast Growth Factors33The Hepatocyte Growth Factor The HGF Receptor, MET34Toll-like Receptors: The Origins of Inflammation35Lymphotoxins36Tumor Necrosis Factor37TRAIL/apo2L38RANK-L : Receptor Activator of NF-kB Ligan39CD95L/FasL its receptor CD95 (APO-1/Fas)40HMGB-1/Amphoterin41EGF Family Ligand42FLT3 Ligand43Stem Cell Factor44Vascular Endothelial Growth Factor45Macrophage Migration Inhibitory Factor (MIF)46Interleukin-8 and other CXC Chemokines47C-C Chemokines48Fractalkine-A Cell Surface Chemokines49Transforming Growth Factor b50Inhibin/Activin Family51Bone Morphogenic ProteinsSection III. Clinical Application of Cytokines and Cytokine Inhibition52Autoimmunity and Cytokines: Pathogenesis and Therapy53Cytokines and Cancer Caligiuri54Interferon alpha: biology, pharmacology, and therapy for chronic viral hepatitis55Haemopoietic Cytokines56Antiangiogenesis57Transplantation58Cytokines and Asthma59Cytokine Gene Transfer60Antisense Therapy61Assays for Cytokines
