Advances in Radiation Biology : Volume 6

著者名：Lett, John T. (EDT)/Adler, Howard (EDT)

Academic Press（2013/10/22発売）

• 言語：ENG
• ISBN：9780120354061
• eISBN：9781483281926

Description

Advances in Radiation Biology, Volume 6, provides an overview of the state of knowledge in the field of radiation biology. The book contains eight chapters and opens with a study on the nature of radiation effects on nucleic acid metabolism in mammalian cells. This is followed by separate chapters on the nature of UV effects on transcriptional functions; interrelationships between ionizing radiation, protein synthesis, and the physiological expressions of radiation damage; and correlation of DNA repair activities and cellular effects in irradiated mammalian cells. Subsequent chapters deal with the interaction of heat and radiation on an in vitro and an in vivo system; the role of hyperthermia for cancer therapy; thermal potentiation of mammalian cell killing; and autologous stem-cell banks for restoring hemopoiesis.

Table of Contents

ContributorsContents of Other VolumesEffects of Ionizing Radiation on Nucleic Acid Synthesis in Mammalian Cells I. Introduction II. Effects of Radiation on the DNA Synthetic Period III. Radiation Effects on DNA Precursor Metabolism and DNA Synthesis IV. Possible Mechanisms Associated with Radiation-Induced Depression of DNA Synthesis V. Ionizing Radiation and RNA Metabolism in the Cultured Mammalian Cell ReferencesUV Damage at the Transcriptional Level I. Introduction II. In Vitro Transcription of UV-Irradiated DNA Templates III. In Vivo Transcription of UV-Irradiated DNA IV. RNA Synthesis in UV-Irradiated Bacteria V. RNA Synthesis in UV-Irradiated Eukaryotic Cells VI. Quantitative Correlation of UV Effects on the Transcriptional Template Functions of DNA VII. Nature of Transcription-Terminating UV Lesions VIII. Investigating Transcriptional Linkage through UV-Induced RNA Chain Termination IX. Concluding Remarks Glossary ReferencesInterrelationships between Ionizing Radiation, Protein Synthesis, and the Physiological Expressions of Radiation Damage I. Introduction II. Interrelationships between Protein Synthesis and the Physiological Expression of Radiation Damage III. Inhibition of Protein Synthesis IV. Conclusions ReferencesRole of DNA Repair in Cell Inactivation, Aging, and Transformation: A Selective Review, A Speculative Model I. Introduction II. DNA Repair in Irradiated Mammalian Cells III. Effects of Radiation in Mammalian Cells IV. A Model for Correlation of DNA Repair Activities and Cellular Effects in Irradiated Mammalian Cells ReferencesResponse of Cells in Vitro and Tissues in Vivo to Hyperthermia and X-Irradiation I. Introduction II. Effect of Hyperthermia Alone in Vitro III. Effect of Hyperthermia Plus Radiation in Vitro IV. Effect of Hyperthermia Alone in Vivo V. Effect of Hyperthermia and Radiation in Vivo VI. Discussion VII. Summary ReferencesExperimental and Clinical Aspects of Hyperthermia Applied to the Treatment of Cancer with Special Reference to the Role of Ultrasonic and Microwave Heating I. Introduction II. Methods of Inducing Hyperthermia III. Mechanisms of Action IV. Effects of Hyperthermia Alone V. Effects of Hyperthermia with Radiation VI. Effects of Hyperthermia with Chemotherapy VII. Microwaves in Cancer Therapy VIII. Ultrasound in Cancer Therapy IX. General Summary and Conclusions ReferencesThermal Potentiation of Mammalian Cell Killing: Clues for Understanding and Potential for Tumor Therapy I. Introduction II. Effect of Heat Alone on Cells III. Theoretical Framework for Thermal and Radiation Experiments IV. Thermal Potentiation of Cell Killing V. DNA, Strand Breaks, Thermal Effects, and Repair VI. Remarks on Thermal Potentiation in Tumor Systems VII. Summary VIII. Conclusion Appendix ReferencesAutologous Stem-Cell Banks for Restoring Hemopoiesis I. Introduction II. Treating the Hemopoietic Syndrome III. Stem Cells in Blood IV. Cryopreservation V. Feasibility VI. Summary ReferencesSubject Index