Nucleotide Metabolism : An Introduction

著者名：Henderson, J. Frank/Paterson, A. R. P.

Academic Press（2014/06/28発売）

• 言語：ENG
• ISBN：9780123405500
• eISBN：9781483261157

Description

Nucleotide Metabolism: An Introduction is a textbook exclusively focusing on the study of the aspects of nucleotide metabolism. The book intends to present the chemistry and metabolism of nucleotides, one of the oldest subjects of biochemistry. The text is divided in two parts. Part I considers the general aspects of nucleotide metabolism such as the history of the discovery of nucleotides; functions of nucleotides in cells; and group-transfer reactions during nucleotide metabolism. Part II deals with the synthesis, formation, and conversion of purine ribonucleotides. Biochemists, pharmacologists, and researchers in the fields of medicine and pharmaceuticals will find the book invaluable.

Table of Contents

ContentsPrefaceNomenclature and Abbreviations Part I. General Aspects of Nucleotide Metabolism Chapter 1. Nucleotides as Tissue Constituents I. Introduction II. Historical Development III. Free Nucleotides of Cells and Tissues References Chapter 2. Configuration and Conformation of Nucleosides and Nucleotides I. Introduction II. The Sugar III. The Bases IV. Base-Sugar Relationships References Chapter 3. Functions of Nucleotides I. Introduction II. Role of Nucleotides in Energy Metabolism III. Transformation of Nucleotide Coenzymes IV. Group-Transfer Reactions of Nucleotide Coenzymes V. Nucleotides as Structural Units VI. Physiological Functions of Nucleotides VII. Regulatory Functions of Nucleotides References Chapter 4. The Three Levels of Phosphorylation I. Transphosphorylation Mechanisms II. Nucleoside Monophosphate Kinases III. Nucleoside Diphosphate Kinases IV. Kinases and the Generation of High-Energy Phosphoryl Groups References Chapter 5. Carbon and Nitrogen Transfer Reactions in Nucleotide Metabolism I. Folic Acid Coenzyme Reactions II. Glutamine Amide Transfer Reactions III. Aspartate Amino Transfer Reactions and Amide Syntheses IV. Phosphoribosyl Transfer Reactions References Chapter 6. Ribose Phosphate Synthesis I. Introduction II. Direct Phosphorylation of Pentoses III. The Pentose Phosphate Pathway IV. Ribose 1-Phosphate Synthesis V. The Formation of Phosphoribosyl Pyrophosphate References Part II. Purine Ribonucleotide Metabolism Chapter 7. Purine Biosynthesis de Novo I. Introduction and Early History II. The Reactions of Purine Biosynthesis de Novo III. Summary of the Pathway IV. Control of Purine Biosynthesis de Novo V. Physiological Significance VI. Summary References Chapter 8. Purine Ribonucleotide Synthesis from Purine Bases and Ribonucleosides I. Introduction and Early History II. Purine Phosphoribosyltransferases III. Purine Ribonucleoside Kinases IV. Anabolic Role of Purine Ribonucleoside Phosphorylase V. Phosphate Transfer Pathway VI. Regulation of Purine Nucleotide Synthesis VII. Summary References Chapter 9. Interconversion of Purine Ribonucleotides I. Introduction and Early History II. Adenylate and Guanylate Synthesis from Inosinate III. Inosinate Synthesis from Guanylate and Adenylate IV. Individual Enzymes V. Function and Operation VI. Regulation VII. Effects of Drugs VIII. Summary References Chapter 10. Catabolism of Purine Nucleotides I. Introduction II. Catabolic Enzymes of Uric Acid Synthesis III. Breakdown of Uric Acid IV. Comparative Aspects of Purine Catabolism V. Urinary Purines Other than Uric Acid VI. Summary References Part III. Pyrimidine Ribonucleotide Metabolism Chapter 11. The de Novo Pathway of Pyrimidine Nucleotide Biosynthesis I. Introduction: Historical Development and Precursors of the Pyrimidine Ring Atoms II. The Orotate Pathway of Uridylate Synthesis III. Origin of the Cytidine Phosphates IV. Regulation of the Orotate Pathway V. Summary References Chapter 12. Pyrimidine Ribonucleotide Synthesis from Bases and Ribonucleosides I. Introduction II. Metabolism of Pyrimidine Bases and Their Ribonucleosides III. Summary References Chapter 13. Catabolism of Pyrimidine Bases I.