Description
Autoantibodies was published and presented in November 2006 at the International Congress of Autoimmunity in Sorrento, a small town in Campania, Italy. The Congress also celebrated the 100th anniversary of the first routine test for autoantibodies. An autoantibody is a type of antibody that is produced by the immune system and that fights one or more of a person's own proteins. These autoantibodies cause autoimmune diseases such as lupus erythematosus. The authors and editors of this book provide a critical review of autoantibodies and their primary functions. They cite a number of major developments in the field of autoantibodies, including the detection of autoantibodies in which a healthy person is a carrier; the discovery that autoantibodies can be both pathogenic and protective in some cases; and the development of a device that will help monitor and detect a specific autoantibody using a small amount of serum and proteomic arrays. Aside from the pathogenic and protective autoantibodies, the book also discusses irrelevant autoantibodies, as these may be relevant for future research. It also addresses the importance of the autoantibodies in a person's body. Clinical physicians, as well as scientists interested in the significance of autoantibodies in the human body, will find this book relevant. It will also be of interest to those who suffer from an autoimmune disease.- Incudes and exhaustive list of autoantibodies not covered by other publications- Short reviews can easily be checked for quick reference information- Both basic and clinical aspects are covered
Table of Contents
I Introduction: Autoantibodies-Unique Characteristics1 What is an Autoantibody?2 Natural Autoantibodies, Heralding, Protecting and Inducing Autoimmunity3 Molecular Mimicry4 Affinity and Avidity of Autoantibodies5 Pathogenic Mechanisms and Clinical Relevance of Autoantibodies6 Native Autoantigens Versus Recombinant Autoantigens7 Redox-Reactive Autoantibodies8 Predictive Autoantibodies9 Autoantibody Subclasses10 Idiotypes and Anti-Idiotypes11 Novel Diagnostic Methods for Autoantibody DetectionII Allergic Disease Autoantibodies12 Human IgE–Specific Autoantibodies and Autoantibodies to IGE ReceptorsIII Antineutrophil Antibodies13 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Myeloperoxidase14 Antineutrophil Cytoplasmic Autoantibodies with Specificity for Proteinase 315 Neutrophil-Specific Antinuclear and Anti-cytoplasmic Antibodies in Chronic Inflammatory Diseases16 Antineutrophil Cytoplasmatic Autoantibodies with Specificity to Proteinase 3IV Introduction: Antinuclear Antibodies17 Antinuclear Antibodies: General Introduction18 Antinucleolar Antibodies19 Anti-Chromatin (Nucleosome) Autoantibodies20 Centromere Autoantibodies21 dsDNA Autoantibodies22 Histone Autoantibodies23 Ku and Ki Autoantibodies24 Neuronal Nuclear Autoantibodies, Type 1 (HU)25 Nuclear Envelope Protein Autoantibodies/Antilamin Autoantibodies26 Anti-Nucleosome Autoantibodies27 Proliferating Cell Nuclear Antigen Autoantibodies28 Anti-RA33 Antibodies (Antibodies to the Heterogeneous Nuclear Ribonucleoprotein A2)29 Anti-Ribosomal P Antibodies30 SS-A (Ro) Autoantibodies31 Topoisomerase-I (Scl-70) Autoantibodies32 SS-B (La) Autoantibodies33 Anti-RNA Polymerase III AntibodiesV Autoantibodies to Biologic Factors/Structures34 GW Bodies, P Bodies and Components of the miRNA Pathway35 Golgi Complex and Endosome Antibodies36 p53 Autoantibodies37 Human Antiganglioside Autoantibodies38 Human Anti--Galactosyl Antibodies39 Autoantibodies in Therapeutic Preparations of Human Intravenous Immunoglobulin (IVIG)40 Cytokine Antibodies41 Cytoskeletal Autoantibodies/Anti-Actin Antibodies42 Fibrillarin Autoantibodies43 Fibronectin Autoantibodies44 Interferon-Inducible Protein IFI16 AutoantibodiesVI Cardiac Autoantibodies45 Autoantibodies in Atherosclerosis46 Heat Shock Protein Autoantibodies47 Myocardial Autoantibodies and their Clinical SignificanceVII Endocrine Autoantibodies48 Glutamic Acid Decarboxylase Autoantibodies49 Humoral Immunity in Type 1 Diabetes Mellitus50 Antibodies to Adrenal, Gonadal Tissues and Steroidogenic Enzymes51 Thyroglobulin, Thyroperoxidase, and Thyrotropin-Receptor AutoantibodiesVIII GI And Liver Autoantibodies52 Anti-Intestinal Goblet Cell Antibodies53 Tumor-Associated Autoantibodies54 Cryoglobulins and Cryoglobulins Secondary to Hepatitis C Virus Infection55 Anti-Tissue Transglutaminase and Anti-Endomyisial Antibodies56 Anti-Gliadin Antibodies57 Reticulin Autoantibodies58 Liver Cytosol Antigen Type 1 Autoantibodies, Liver Kidney Microsomal Autoantibodies, and Liver Microsomal Autoantibodies59 Antimitochondrial Antibodies60 Parietal Cell and Intrinsic Factor Autoantibodies61 Smooth Muscle AntibodiesIX Hematologic Autoantibodies62 Coagulation Factor Autoantibodies63 Autoantibodies in Heparin-Induced Thrombocytopenia64 Platelet Autoantibodies65 Red Cell Autoantibodies66 Lymphocytotoxic AutoantibodiesX Kidney Autoantibodies67 Anti-ATP Synthase β-Chain Autoantibodies68 Glomerular Basement Membrane Autoantibodies69 Nephritic Factor AutoantibodiesXI Neurological System Autoantibodies70 Acetylcholine Receptor and Muscle Specific Kinase Autoantibodies71 Myositis Autoantibodies: Aminoacyl-tRNA Synthetase, Signal Recognition Particle, Mi-2, and PM-Scl Autoantibodies72 Anti-MOG Antibodies73 Antibodies to Hsp 70 in Inner Ear Disease74 Autoantibodies in the Lambert–Eaton Myasthenic Syndrome (LEMS) and Amyotrophic Lateral Sclerosis (ALS)75 Ganglioside Autoantibodies76 Myelin Associated Antibodies: Myelin-Associated Glycoprotein Autoantibodies
