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Advances in Radiation Biology, Volume 4 provides wide-ranging analyses of progress in the various phases of radiation biology. This book discusses the repair processes for photochemical damage in mammalian cells; S-phase recovery or postreplication repair; enzymes involved in the repair of DNA; and reinsertion of nucleotides. The mutation induction in mice; dominant visible mutations; experimental radiation carcinogenesis; and dose-effect relationships are also deliberated. This text likewise covers the toxicology of plutonium; effects of ionizing radiation on terrestrial plant communities; and radiation sensitivities of plant communities. This publication is beneficial to radiation biologists, as well as students and researchers conducting work on radiobiology.
Table of Contents
ContributorsPrefaceContents of Other VolumesRepair Processes for Photochemical Damage in Mammalian Cells I. Introduction II. Excision Repair III. S-Phase Recovery or Postreplication Repair IV. Photoreactivation V. Some Implications and Conclusions ReferencesEnzymes Involved in the Repair of DNA I. Introduction II. Incision Step III. Excision Mechanisms IV. Pre-Reinsertion Mechanisms V. Reinsertion of Nucleotides VI. Sealing of the Final Phosphodiester Bond VII. Conclusions ReferencesMutation Induction in Mice I. Introduction II. Gametogenesis III. Specific Locus Mutations IV. Dominant Visible Mutations V. Skeletal Mutations VI. Histocompatibility Mutations VII. Recessive Visible Mutations VIII. Recessive Lethal Mutations IX. Summary ReferencesExperimental Radiation Carcinogenesis I. Introduction II. General Considerations on the Significance of Animal Data for Radiation Carcinogenesis III. Tissues at Risk IV. Dose-Effect Relationships V. Relative Biological Effectiveness (RBE) VI. Effect of Dose Rate VII. Dependence of Sensitivity on Age VIII. Differences in Sensitivity between Strains and between Species IX. Summary ReferencesToxicology of Plutonium I. Introduction II. Properties of Plutonium of Biomedical Interest III. Disposition of Plutonium in the Body IV. Biological Effects V. Countermeasures for Plutonium Contamination VI. Concluding Comments ReferencesEffects of Ionizing Radiation on Terrestrial Plant Communities I. Introduction II. Methods of Study III. Types of Effects Observed IV. Recovery of Radiation-Damaged Plant Communities V. Radiation Sensitivities of Plant Communities VI. Concluding Remarks ReferencesThe Breakage-and-Reunion Theory and the Exchange Theory for Chromosomal Aberrations Induced by Ionizing Radiations: A Short History I. Introduction II. Chromosomal Aberrations III. The Development of Breakage-and-Reunion Theory IV. The Exchange Theory V. Implications of the Exchange Theory for Aberration Development VI. Some Questions and Objections VII. Further Evidence for and against the Exchange Theory VIII. Conclusions ReferencesAuthor IndexSubject Index
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