Description
Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting.- Serves as the definitivereference for molecular pathologists worldwide- Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics- Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science
Table of Contents
I. Introduction and Methodology Quantivative PCR: an introductionSignal Amplification Methods in Molecular DiagnosticsThe Lab-on-a-Chip Approach for Molecular DiagnosticsNucleic Extraction and AmplificationGeneral Procedures II. Quality Assurance, Regulatory, and Ethical Issues Billing and Reimbursement for Molecular DiagnosticsMolecular Pathology and Infectious DiseasesEthical Considerations in Molecular DiagnosticsQuality Control, Assurance, Identification and Standards III. Genetic Disease Molecular Testing for Cystic Fibrosis and CFTR-Related ConditionsCarrier Testing for Neurogenetic DiseasesHemochromatosisStandards and Recommendations for Molecular Diagnostic Testing for Huntington Disease, the Autosomal Dominant Spinocerebellar Ataxias, and Friedreich Ataxia IV. Cancer The Role of Micro-RNAs in CancerMolecular Diagnostics in the Evaluation of Cancer: Modern Concepts and OverviewGene Expression Analysis for Tumor Profiling GEA for TPMolecular Diagnostics of Hematopoetic Malignancies V. Infectious Diseases VirusesHepatic B and C VirusesMolecular Diagnosis of CytomegalovirusMolecular Detection of Multiple Respiratory VirusesBacteriaMolecular Methods for Identification and Characterization of Acinetobacter speciesMolecular Detection and Surveillance of Healthcare-Associated InfectionsMolecular Detection Of Group B StreptococcusRole of Molecular Techniques in the Epidemiologic Investigation Of Hospital-Acquired InfectionsHuman Papilloma Virus and its Role in Cervical Carcinoma VI. Specialized Applications of Molecular Testing Molecular HLA Typing Methods Used in Clinical LaboratoriesIdentification through DNA analysis in criminal and family relatedness investigations.VII. Pharmacogenetics Overview of Pharmacogenomics and Applications for the Modern Clinical LaboratoryUDP-Glucuronosyltransferase 1A1 and the Glucuronidation in Oncology Applications and HyperbilirubinemiaPharmacogenetics of P-450 EnzymesPharmacogenomics of Thiopurine Methyl Transferase (TPMT): Importance in Monitoring of Mercaptopurine/Azathioprine Therapy
