Description
In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the "epigenome, comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach.This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA.- Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches- Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome- Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs
Table of Contents
Section I: Post-Genomic Cardiology 1. Introduction to the Molecular Biology of the Cell2. Methodologies in the Era of Cardiovascular "Omics 3. Post-Genomics Cardiovascular Signaling PathwaysSection II: Pediatric Cardiology in the Post-Genomic Era 4. Molecular Determinants of Cardiac Development 5. Molecular Determinants of Congenital Heart DiseaseSection III: Post-Genomic Assessment of Coronary Artery Disease, Angiogenesis, and Hypertension 6. Molecular Determinants of Atherosclerosis7. Molecular Genetics of Coronary Artery Disease and Myocardial Infarction 8. Cellular and Molecular Aspects of Cardioprotection 9. Molecular Determinants of Cardiac Neovascularization 10. Post-Genomics Appraisal of Systemic and Pulmonary HypertensionSection IV: Post-Genomic Analysis of the Myocardium 11. Post-Genomic Appraisal of Myocarditis 12. Cardiomyopathies: A Comparative Analysis of Phenotypes and GenotypesSection V: Heart Failure, Cell Death, and Mitochondria Dynamics 13. Gene Profiling, Energy Metabolism, and Remodeling of the Failing Heart14. Oxidative Stress and Cell Death in Cardiovascular Disease: A Post-Genomic Appraisal 15. The Emerging Role of Mitochondrial Dynamics in Cardiovascular DiseaseSection VI: Molecular and Genetic Analysis of Metabolic Disorders 16. Post-Genomic Analysis of Fatty Acid and Glucose Metabolism in Cardiovascular DiseaseSection VII: Molecular Genetics of Dysrhythmias 17. Post-Genomic Analysis of Dysrhythmias and Sudden DeathSection VIII: Genes, Gender, and Epigenetics 18. Gender and Cardiovascular Disease in the Post-Genomic EraSection IX: Aging and the Cardiovascular System 19. The Aging Heart: A Post-Genomic Appraisal 20. Targeted Strategies to Fight Cardiac Aging21. Aging and the Cardiovascular System: The Road AheadSection X: Genetics, Epigenetics, and New Approaches to Treatment 22. Epigenetics and Cardiovascular Disease23. Gene- and Cell-Based Therapy for Cardiovascular DiseaseSection XI: Looking to the Future24. The Path to Personalized Cardiovascular Medicine
