Description
Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs.The book describes the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions.- It provides comprehensive information on hCG from basic science to clinical medicine- Written by specialists in the field
Table of Contents
INTRODUCTION Chapter 1: THE EXPANDING WORLD OF hCGRobert HussaChapter 2: HISTORY AND INTRODUCTION TO HUMAN CHORIONIC GONADOTROPIN (hCG): ONE NAME FOR AT LEAST THREE INDEPENDENT MOLECULES Laurence ColeChapter 3: INTRODUCTION TO PREGNANCY IMPLANTATION, VILLOUS FORMATION, AND HEMOCHORIAL PLACENTATION Laurence ColeGENETICS, SYNTHESIS, SECRETION, STRUCTURE, AND DEGRADATION OF hCGChapter 4: THE MOLECULAR GENETICS OF hCG Stephen ButlerChapter 5: STRUCTURE, SYNTHESIS, SECRETION, AND FUNCTION OF hCG Laurence Cole, PhD and Stephen ButlerChapter 6: COMPARISSON OF STRUCTURES OF hCG AND HYPERGLYCOSYLATED hCG Laurence ColeChapter 7: STRUCTURES OF FREE α-SUBUNIT AND FREE ß-SUBUNIT Laurence ColeChapter 8: GLYCOBIOLOGY OF hCGAkira KobataChapter 9: DEGRADATION PRODUCTS OF hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNITLaurence ColeChapter 10: THE THREE DIMENSIONAL STRUCTURE OF hCGLaurence ColeBIOLOGICAL FUNCTION OF hCGChapter 11: PARADIGM SHIFT ON THE TARGETS OF hCG ACTIONSCV RaoChapter 12: THE hCG RECEPTORLaurence Cole and Stephen ButlerChapter 13: BIOLOGICAL FUNCTIONS OF HYPERGLCOSYLATED hCGLaurence ColeChapter 14: BIOLOGICAL FUNCTION OF THE FREE BETA SUBUNIT: EXPRESSION AND TREATMENT TARGET IN CANCERSteven Butler and Ray IlesCLINICAL APPLICATIONSChapter 15: USE OF hCG IN REPRODUCTIVE DYSFUNCTIONCisco ByrnChapter 16: hCG IN THE IVF CLINICErvin Jones, Chapter 17: ILLICIT USE OF hCG IN DIETARY PROGRAMS AND USE TO PROMOTE ANABOLISM Laurence Cole hCG TESTSChapter 18: ANTIBODYS FOR INTACT hCG, TOTAL hCG, FREE SUBUNITS, GLYCOSYLATION VARIANTS, AND hCG FRAGMENTSLaurence ColeChapter 19: QUANTITATIVE hCG ASSAYSLaurence ColeChapter 20: FALSE-POSITIVE hCG ASSAYS Laurence ColeChapter 21: SPECIFICITY OF DIFFERENT hCG ASSAYSLaurence ColeChapter 22: POINT-OF-CARE PREGNANCY TESTS Laurence Cole Chapter 23: OVER-THE-COUNTER PREGANCY TESTS Laurence Cole Chapter 24: hCG STANDARDS Ulf Stenman TEST APPLICATIONSChapter 25: BACKGROUND hCG Laurence Cole Chapter 26: PREGNANCY TESTINGLaurence Cole Chapter 27: PREDICTING SPONTANEOUSLY ABORTED (SAB) PREGNANCIES Laurence ColeChapter 28: hCG, HYPERGLYCOSYLATED hCG, AND FREE ß-SUBUNIT IN PREDICTING DOWN SYNDROME PREGNANCIES AND PREECLAMPSIA Laurence ColeChapter 29: hCG IN MONITORING GESTATIONAL TROPHOBLASTIC DISEASESLaurence ColeChapter 30: USE OF HYPERGLYCOSYLATED hCG AS A UNIQUE MARKER OF GESTATIONAL TROPHOBLASTIC NEOPLASMSLaurence Cole and Carolyn MullerChapter 31: PITUITARY hCG AND FAMILIAL hCG Laurence Cole Chapter 32: hCG, FREE ß-SUBUNIT AND ß-CORE FRAGMENT AS MARKERS OF MALIGNANCIES Laurence Cole BASIC METHODSChapter 33: hCG AND HYPERGLYCOSYLATED HCG PURIFICATION FROM SERUM, URINE, AND CULTURE FLUIDSLaurence ColeChapter 34: DISSOCIATION, DESIALYLATION, AND CLEAVAGE OF HCGLaurence ColeChapter 35: hCG AND FREE ß-SUBUNIT PRODUCING CELL LINESLaurence Cole EVOLUTION, SUMMARY AND THE FUTUREChapter 36: EVOLUTION OF hCG, EVOLUTION OF HUMANS, EVOLUTION OF HUMAN PREGNANCY DISORDERS AND CANCERLaurence ColeChapter 37: SUMMARY: hCG A REMARKABLE MOLECULELaurence ColeChapter 38: hCG AND THE FUTURE Laurence Cole
