Description
Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students.Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Table of Contents
ContributorsForewordPrefacePart I Pumping Action and Electrical Activity of the Heart 1. Sequence of Cardiac Activation and Ventricular Mechanics 2. Coronary Circulation and Hemodynamics 3. Neurohumoral Control of Cardiac Function 4. Control of Cardiac Output and its Alterations during Exercise and in Heart Failure 5. Ultrastructure of Cardiac Muscle and Blood Vessels 6. Excitability and Impulse Propagation 7. Electrocardiogram and Cardiac Excitation 8. Gap-Junction Channels and Healing-Over of InjuryPart II Cellular Electrophysiology of Heart and Vascular Smooth Muscle 9. Electrogenesis of the Resting Potential 10. Cardiac Action Potentials 11. Electrophysiology of Vascular Smooth Muscle 12. Sodium Channels 13. Voltage-Dependent Calcium Channels 14. Voltage-Dependent K+ Channels 15. Inwardly-Rectifying K+ Channels in the Heart 16. Voltage and Calcium-Activated K+ Channels of Coronary Smooth Muscle 17. Ion Channels in Vascular Smooth Muscle 18. Cardiac Pacemaker Currents 19. Chloride Channels in Heart 20. Regulation of Cardiac Ion Channels by Phosphorylation, Ca2+, Cytoskeleton, and StretchPART III PUMPS AND EXCHANGERS 21. Cardiac Na+/K+ Pump 22. Cardiac Na+–Ca2+ Exchanger: Pathophysiology and Pharmacology 23. Na+/H+ Exchanger and pH Regulation 24. Transport in Nucleus 25. Sarcoplasmic Reticulum Ca2+ Transport 26. Calcium Release from Cardiac Sarcoplasmic ReticulumPart IV Vascular Endothelium 27. Function of Vascular Endothelium 28. Ion Channels in Vascular EndotheliumPart V Excitation–Contraction Coupling and Pharmacomechanical Coupling 29. Electromechanical and Pharmacomechanical Coupling in Vascular Smooth Muscle Cells 30. Mechanisms Regulating Cardiac Myofilament Response to Calcium 31. Vascular Smooth Muscle ContractionPart VI Metabolism and Energetics 32. Myocardial Energy Metabolism 33. Metabolism and Energetics of Vascular Smooth MusclePart VII Signaling Systems 34. Adrenergic Receptors in the Cardiovascular System 35. Cardiac Action of Angiotensin II 36. ATP and Adenosine Signal Transductions 37. Kinase Signaling in the Cardiovascular System 38. Calcium Signaling 39. Diadenosine Polyphosphate Signaling in the HeartPart VIII Developmental Changes and Aging 40. Cardiac Development and Regulation of Cardiac Transcription 41. Developmental Changes of Ion Channels 42. Aging of the Cardiovascular System 43. Changes in Autonomic Responsiveness during DevelopmentPart IX Mechanism of Action of Cardioactive Drugs 44. Inotropic Mechanism in Cardiac Muscle 45. Mechanisms of Action of Calcium Antagonists 46. Cyclic Nucleotides and Protein Phosphorylation in Vascular Smooth Muscle Relaxation 47. K+ Channel Openers 48. Mode of Action of Antiarrhythmic DrugsPart X Pathophysiology 49. Cellular Mechanisms of Cardioprotection 50. Ischemic Preconditioning: Description, Mechanism, and Significance 51. Cardioplegia and Surgical Ischemia 52. Apoptosis 53. Calcium Overload in Ischemia/Reperfusion Injury 54. Coronary Atherosclerosis and Restenosis 55. Diabetic Vascular Disease 56. Angiogenesis and Coronary Collateral Circulation 57. Molecular Pathophysiology of Cardiomyopathies 58. Signal Transduction of Cardiac Myocyte Hypertrophy 59. Electrophysiological Changes in Hypertrophy 60. Molecular Basis of Inherited Long QT Syndromes and Cardiac Arrhythmias 61. Molecular Mechanisms of Atrial Fibrillation 62. Lipids Released during Ischemia and Arrhythmogenesis 63. Ion Channels in the Heart 64. Cardiac Arrhythmias: Reentry and Triggered Activity 65. Myocardial Reperfusion Injury—Role of Free Radicals and Mediators of Inflammation 66. Cardiac Toxicology 67. Regulation of Gene Expression by Hypoxia 68. Gene Transfer in Cardiovascular TherapyIndex
