Description
ABC Proteins is an in-depth, up-to-date analysis of all that is known about the subject to date. It discusses and compares evolution, biology and mechanism of action of all known ABC proteins, including the first structural studies as well as clinical implications. It will be useful to anyone trying to stay abreast of the latest findings. This book is sure to become a classic and will regularly be updated.- Phylogeny and Evoloution of ABC Transporters- Fundamental Aspects of the Mechanism of Action of ABC Transporters- Prokaryote ABC Transporters- Non-Mammalian Transporters- Multidrug Transporters- ABC Transporters, Physiological Roles and Human Disease- Full color throughout
Table of Contents
PART 1-PHYLOGENY AND EVOLUTION OF ABC-TRANSPORTERSPhylogenetic and Functional Classification of ABC (ATP-binding cassette) SystemsMembrane Topology of the Human ABC Transporter ProteinsHuman and Drosophila ABC-Proteins PART 2-FUNDAMENTAL ASPECTS OF THE MECHANISM OF ACTION OF ABC-TRANSPORTERSStructure and Modular Organization of ABC-TransportersSubstrate Binding Sites in ABC-TransportersProbing of Conformational Changes,Catalytic Cycle and ABC-Transporters FunctionX-ray Structure of an Intact ABC-Transporter, MsbAPART 3-PROKARYOTE ABC-TRANSPORTERSIntroduction to Bacterial ABC-Transport SystemsImport of Solutes by ABC-Transporters-The Maltose SystemCrystal Structures of Periplasmic Solute Binding Proteins in ABC-Transport Complexes Illuminate their FunctionBacterial ABC-Transporters Involved in Protein TranslocationBacterial Multidrug Resistance Mediated by ABC-TransportersStructure and Function of Osmoregulated ABC Transporters PART 4 -NON-MAMMALIAN EUKARYOTE ABC-TRANSPORTERSInventory & Evolution of Fungal ABC Protein Genes.Fungal ABC Proteins in Clinical Drug Resistance & Cellular DetoxificationDrug Resistance Mediated by ABC Transporters in Parasites of HumansThe Plant ABC Transporter Superfamily: the Functions of a Few and Identities of ManyPART 5-MAMMALIAN MULTIDRUG RESISTANCE ABC-TRANSPORTERSSolving the Problem of Multidrug Resistance: ABC Transporters in Clinical OncologyMultidrug Resistance Protein 1 (ABCC1)MRP2, the Apical Export Pump for Anionic Conjugates The Multidrug Resistance Proteins 3-7Lipid Transport by ABC TransportersRole of ABCA1 in Cell Turnover and Lipid HomeostasisPeroxisome ABC-Transporters ABC-Transporters in Mitochondria The Transporter Associated with Antigen Processing (TAP): A Peptide Transport and Loading Complex Essential for Cellular Immune ResponsesThe Sulphonylurea Receptor: an ABCC Transporter that Acts as an Ion Channel RegulatorABC-Transporters and Human Eye DiseaseStructure Function Analysis of CFTR
