Description
Electrospinning is a simple and highly versatile method for generating ultrathin fibres with diameters ranging from a few micrometres to tens of nanometres. Although most commonly associated with textile manufacturing, recent research has proved that the electrospinning technology can be used to create organ components and repair damaged tissues. Electrospinning for tissue regeneration provides a comprehensive overview of this innovative approach to tissue repair and regeneration and examines how it is being employed within the biomaterials sector.The book opens with an introduction to the fundamentals of electrospinning. Chapters go on to discuss polymer chemistry, the electrospinning process, conditions, control and regulatory issues. Part two focuses specifically on electrospinning for tissue regeneration and investigates its uses in bone, cartilage, muscle, tendon, nerve, heart valve, bladder, tracheal, dental and skin tissue regeneration before concluding with a chapter on wound dressings. Part three explores electrospinning for in vitro applications. Chapters discuss cell culture systems for kidney, pancreatic and stem cell research.With its distinguished editors and international team of expert contributors, Electrospinning for tissue regeneration is a valuable reference tool for those in academia and industry concerned with research and development in the field of tissue repair and regeneration.- Provides a comprehensive overview of this innovative approach to tissue repair and regeneration covering issues from polymer chemistry to the regulatory process- Examines employment within the biomaterials sector, reviewing extensive applications in areas such as uses in bone, muscle tendon, heart valve and tissue regeneration- Explores electrospinning for in vitro applications and discusses cell culture systems for kidney, pancreatic and stem cell research
Table of Contents
Contributor contact detailsPart I: Fundamentals of electrospinningChapter 1: Introduction to electrospinningAbstract:1.1 Introduction1.2 Basic concepts1.3 Morphology and structural formation1.4 Parameters1.5 Apparatus1.6 Materials1.7 Applications1.8 Future trendsChapter 2: Polymer chemistryAbstract:2.1 Introduction2.2 Natural polymers2.3 Synthetic degradable polymers2.4 ConclusionsChapter 3: The electrospinning process, conditions and controlAbstract:3.1 Introduction3.2 Solution parameters3.3 Processing parameters3.4 Ambient parameters3.5 ConclusionsChapter 4: Regulatory issues relating to electrospinningAbstract:4.1 Introduction4.2 Regulation of materials in regenerative medicine4.3 Future trends4.4 Sources of further information and advicePart II: Electrospinning for tissue regenerationChapter 5: Bone tissue regenerationAbstract:5.1 Introduction5.2 Principles of bone biology5.3 Strategies for bone regeneration5.4 Fabrication of scaffolds for bone tissue engineering5.5 Potential materials for scaffolds5.6 Osteoporosis: a growing problem5.7 Strategies for the treatment of bone defects5.8 Conclusions and future trendsChapter 6: Cartilage tissue regenerationAbstract:6.1 Introduction6.2 Culture of chondrogenic cells for implantation6.3 Electrospun nanofibre scaffolds6.4 Future trendsChapter 7: Muscle tissue regenerationAbstract:7.1 Introduction to skeletal muscle7.2 Skeletal muscle injuries7.3 Mechanical properties of skeletal muscle7.4 Tissue engineering7.5 Contractile force7.6 Conductive elements7.7 Conclusion and future trendsChapter 8: Tendon tissue regenerationAbstract:8.1 Introduction: tendon tissue8.2 Tendon structure and composition8.3 Tendon pathology8.4 Clinical need8.5 Tissue engineering8.6 Cell response to electrospun bundles8.7 Mechanical properties of electrospun bundles8.8 Conclusions and future trends8.9 AcknowledgementsChapter 9: Nerve tissue regenerationAbstract:9.1 Introduction9.2 Clinical problems in nerve tissue therapy9.3 Nerve tissue engineering9.4 Biomimetic nanoscaffolds for peripheral nerve regeneration9.5 Stem cell therapy with nanofibre for nerve regeneration9.6 Conclusion and perspectivesChapter 10: Heart valve tissue regenerationAbstract:10.1 Introduction10.2 Tissue to be replaced: heart valves10.3 Specific tissue requirements as a blueprint for scaffold properties10.4 Selection of scaffold material10.5 Scaffold properties to meet tissue requirements10.6 Future trends10.7 AcknowledgmentChapter 11: Bladder tissue regenerationAbstract:11.1 Structural/functional properties of the bladder11.2 Bladder disease and the need for bladder substitution11.3 Electrospun and other scaffolds for bladder tissue engineering11.4 Electrospinning fit for purpose11.5 Future trends11.6 Conclusions11.7 AcknowledgementChapter 12: Tracheal tissue regenerationAbstract:12.1 Anatomy of the trachea and main pathologies of surgical concern12.2 Tissue engineered trachea (TET)12.3 Electrospun biodegradable tubular tracheal scaffold12.4 Scaffold fulfilment12.5 In vitro and in vivo evaluation of the cell and tissue response12.6 Conclusions12.7 AcknowledgementsChapter 13: Dental regenerationAbstract:13.1 Introduction13.2 Periodontal regeneration13.3 Reinforcement of dental restorations13.4 Conclusions and future trendsChapter 14: Skin tissue regenerationAbstract:14.1 Introduction14.2 Biology of skin and wound healing14.3 Challenging problems in existing therapies14.4 Restoring functional skin tissue14.5 Nanofibres as extracellular matrix analogue14.6 Ideal properties of scaffold14.7 Choice of biomaterial14.8 Cellular interactions on skin substitute14.9 Conclusions and future trendsChapter 15: Wound dressingsAbstract:15.1 Introduction: wound healing15.2 Nanofibres15.3 Antimicrobial nanofibrous wound dressings15.
