Full Description
This book comprehensively reviews the role of cancer stem cells (CSCs) in cancer initiation, progression, and resistance to anticancer therapies. The initial chapters examine the methods and procedure of the detection, isolation, and characterization of CSCs. It also introduces various epigenetic pathways that contribute to cancer initiation and tumorigenesis, particularly regarding the maintenance and survival of CSCs. It also explores the role of CSCs metabolism and the mechanisms of metabolic plasticity of CSCs in cancer biology. Further, it also presents the implications of CSCs on the origin of tumor heterogeneity and on heterogeneity of the therapeutic response. Towards the end, this book highlights the different immunotherapeutic approaches targeting CSCs with the potential of strongly improving cancer outcomes. This book offers a broad framework to scientists and clinicians into the state-of-the-art knowledge on cancer stem cell biology and highlights their therapeutic implications.
Contents
1. Introduction and perspective in carcinogenesis.- 2. Origin and Development of Cancer Stem Cells.- 3. Detection and Isolation of Cancer Stem Cells.- 4. The genetic and epigenetic landscape of cancer stem cells.- 5. Metabolism of Cancer Stem Cell.- 6. Plasticity of Cancer Stem Cell.- 7. Cancer Stem Cells in Cancer Initiation and Progression.- 8. Cancer Stem Cells and Metastasis.- 9. Roles of Cancer Stem Cells in Therapy resistance and Disease Recurrence.- 10. Novel therapeutics targeting cancer stem cell surface markers.- 11. Therapeutics targeting cancer stem cells signalling pathways.- 12. Cancer stem cells therapeutics delivery and EPR effect.- 13. Immunotherapy against cancer stem cells.- 14. Engineering nanobody targeting cancer stem cells.- 15. Biological barriers for drug delivery to cancer stem cells.- 16. Cancer Stem Cell Markers in Haematological Malignancies.- 17. Diagnostic and Prognostic Significance of Cancer Stem Cells Surface Markers.- 18. Diagnostic and prognostic implications of cancer stem cells transcription factors.- 19. Diagnostic and prognostic significance of intracellular markers of CSCs in patients with cancers.
