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Full Description
The second edition of this book presents the role of osmolytes in human health and diseases. Some of the chapters deal about the possibility of the use of osmolytes as diagnostic biomarkers and potential drug design for neurodegenerative and other human diseases. Other chapters also include reviews on the role of osmolytes in cancer, metastasis, infectious diseases, metabolic disorders, immunological disorders, and tissue regeneration. Importantly, the book also contain recent updates on the role of naturally occurring osmolytes in protein folding pathway, protein stability, and their underlying mechanisms. The book also covers the aspects that osmolytes could promote conformational alterations of transcription factors that favor metastatic behavior. Potential of the osmolytes in the various process of vaccine development, including enhancing the efficacy, production, and purification steps are also succintly described. Towards the end, the book also elucidates the use of specific molecules for the prevention of toxic gain of functions and restoration of function to disease-causing mutant protein. This book is an invaluable asset for the researchers especially working in osmolyte biology and scientists involved in basic and clinical research particularly neurodegeneration, diabetes, cancer, and metabolic disorders.
Contents
Chapter 1_Protein folding pathways in the presence of osmolytes.- Chapter 2_Effect of Organic Osmolytes on protein folding Intermediates.- Chapter 3_Role of TMAO on folding behavior of various proteins associated with neurodegeneration.- Chapter 4_Osmolyte-Mediated Protein Stabilization: Unraveling Interactions Across Conformational Landscapes.- Chapter 5_Osmolytes as a promising therapeutic strategy for protein aggregation diseases.- Chapter 6_Involvement of osmolytes in the pathophysiology of various human diseases.- Chapter 7_Role of osmolytes in cancer.- Chapter 8_Harnessing the power of osmolyte for industrial and pharmaceutical applications.- Chapter 9_Diverse biological functions of Myoinositol: A neuro-metabolite, osmoprotectant and diagnostic marker.- Chapter 10_Potential of osmolytes as Diagnostic Biomarkers in various Diseases.- Chapter 11_Osmolytes as stress sensors in plants: Acclimatizing plants under stress conditions.
