Full Description
The book presents novel carrier systems for the targeted and controlled drug delivery for the treatment of various diseases which are difficult to be treated with conventional drug delivery systems like cancer, autoimmune disorders, and emerging infectious diseases. It also reviews the origins and applications of stimuli-responsive polymer systems and polymer therapeutics such as polymer-protein and polymer-drug conjugates. The book also explores the potential applications of the parenteral route of administration for the delivery of active pharmaceutical substances with a narrow therapeutic index and poor bioavailability. Further, the book presents common routes of administration for the systemic delivery of peptides and proteins. It also examines the applications of various implantable systems in drug delivery. The book also covers the important colloidal drug delivery systems, including liposomes and niosomes and solid lipid nanoparticles, and nanostructured lipid carriers. Towards,the end, the book discusses the therapeutic potential of biodegradable polymeric nanoparticles for controlled drug delivery. Authoritative and thorough, this book is a valuable resource for researchers working on a multidisciplinary approach to employing drug delivery systems.
Contents
Chapter 1_Fundamentals of targeted drug delivery.- Chapter 2_Influence of drug properties and routes of drug administration on design of sustained and controlled release systems.- Chapter 3_Polymeric materials in controlled drug delivery.- Chapter 4_Biopharmaceutic and pharmacokinetic aspects of peroral Controlled Drug Delivery Systems.- Chapter 5_Parenteral drug delivery.- Chapter 6_Proteins / peptides drug delivery systems.- Chapter 7_Transdermal / skin drug delivery system.- Chapter 8_Implantable Therapeutics Systems.- Chapter 9_Chemical drug delivery systems.- Chapter 10_Targeted brain delivery.- Chapter 11_Targeted Tumor Delivery.- Chapter 12_Miscellaneous targeting approaches: Fundamentals of gene delivery, Overview of colon, liver, macrophage, mitochondrial and M cells targeting.- Chapter 13_Overview of Specialized drug delivery systems: Transfersomes, Ethosomes, Layersomes, Bilosomes,Emulsomes, Virosomes, Cubosomes, Aquasomes, Pharmacosomes. Dendrimers, Polymeric Micelles and Resealed Erythrocytes.- Chapter 14_Controlled release formulations for alternate routes of administration.- Chapter 15_Stimuli responsive drug delivery systems: Magnetically, thermal and pH-assisted drug delivery systems.- Chapter 16_Role of controlled release in veterinary formulations.- Chapter 17_Colloidal drug delivery systems: (a) Liposomes and niosomes.- Chapter 18_Solid lipid nanoparticles and nanostructured lipid carriers.- Chapter 19_Polymeric nanoparticles - PLGA, chitosan, albumin, gelatin, alginate etc and Carbon nanotubes.- Chapter 20_Theranostics Application of Controlled Release Drug Delivery systems.- Chapter 21_Regulatory approval pathways involved in controlled release formulations.
