Full Description
O-linked N-acetylglucosamine (O-GlcNAc) is a prevalent post-translational modification of numerous intracellular proteins. This modification has recently emerged as a key regulator of various important biological processes, including gene transcription, stress response, metabolic homeostasis, and immune regulation. Given the critical role of O-GlcNAc in normal physiology, increasing evidence has now demonstrated that deregulation of O-GlcNAc is closely associated with the development and progression of various diseases, including neurodegeneration, cardiovascular disease, and cancer. This book provides a comprehensive overview of the current progress and understanding of this modification in biology, and likely provides new research directions in the future.
Contents
Chapter 1. Chemical tools for decoding the functions of O-GlcNAcylation.- Chapter 2. Profiling O-GlcNAcylation with mass spectrometry.- Chapter 3. O-GlcNAcylation and cell metabolism.- Chapter 4. O-GlcNAcylation and transcriptional regulation and epigenetics.- Chapter 5. O-GlcNAcylation and signal transduction.- Chapter 6. O-GlcNAcylation and stem cells.- Chapter 7. O-GlcNAcylation and immune regulation.- Chapter 8. O-GlcNAcylation and neuronal development, neurodegeneration and neurological disorders.
