Full Description
This book describes the development of animal models widely used in biomedical research using step-wise instructions and photographs. Showcasing a wide range of species from zebra fishes, birds, rodents, rabbits, dogs, and pigs, the book includes detailed methodology on how to work with these species and to develop various models. The animal models in neurology including stroke, Alzheimer's disease, Parkinson's disease, and Schizophrenia; Animal models in cancer research, sleep disorders, and cardiovascular diseases are described to meet the understanding of researchers who plan to replicate these models in their laboratories. In depth detailing on the development of targeted gene knockouts and transgenics, implantation models that are used in toxicology studies, and pharmacokinetic studies in pigs and dogs are a highlight. Further, the book describes pharmacologic, chemically induced, surgically induced, microbiologically induced, infectious models, models for neurobehavioral studies, oncology research, and pain research. The book has dedicated sections on anesthesia and analgesia and teaches procedures like venous cut-downs and cannulations in pigs and dogs, and endotracheal intubation, mechanical ventilation and thoracotomy in rodents and will serve as a self-training tool. Concepts in the field of animal model development are explained using examples. Sample size selection, study design, and statistical evaluation of experiments involving laboratory animals are explained to enable young researchers to practically understand the nuances. This book will be a valuable tool for academicians, students, scientists, and veterinarians and will benefit equally who are new to the field and who are already working with laboratory animals.
Contents
1. The Key Concepts of Animal Models.- 2. Ethics Welfare, 3R's & Legislation in Biomedical Research- A Practical Approach.- 3. Experimental Design and Statistics in Animal Research.- 4. New Approach Methodologies: Rethinking Preclinical Evaluation of Pharmaceuticals and Medical Devices Beyond Animal Models.- 5. Basic techniques to facilitate small animal experimentation.- 6. Zebrafish: An animal model in biomedical research.- 7. Avian Models for Biomedical Research.- 8. The naked mole-rat (Heterocephalus glaber): a promising non-traditional model for biomedical research.- 9. Pharmacologically induced Animal models for various Diseases.- 10. Animal Models for Gut Microbiome Research.- 11. Animal Model for Alzheimer's disease, Parkinson's disease and Schizophrenia.- 12. Animal models in sleep research.- 13. Animal Models for Pain Research.- 14. Animal models in cancer research: Revolutionizing the field of oncology.- 15. Animal models of infectious diseases.- 16. Modeling Ischemic Stroke by Middle Cerebral Artery Occlusion in Rats.- 17. Dog as an animal model in preclinical research.- 18. Swine as an animal model in preclinical research.- 19. Evaluation of Biomaterials- Histopathology Techniques Used in the Screening of Biomaterials to Ensure Biocompatibility.- 20. Methods in Toxicologic Pathology.
