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Full Description
The enormous advances in the immunologic aspects of biotherapeutics and nanomedicines in the past two decades has necessitated an authoritative and comprehensive reference source that can be relied upon by immunologists, biomedical researchers, clinicians, pharmaceutical companies, regulators, venture capitalists, and policy makers alike. This text provides a thorough understanding of immunology, therapeutic potential, clinical applications, adverse reactions, and approaches to overcoming immunotoxicity of biotherapeutics and nanomedicines. It also tackles critical, yet often overlooked topics such as immune aspects of nano-bio interactions, current FDA regulatory guidances, complement activation-related pseudoallergy (CARPA), advances in nanovaccines, and immunogenicity testing of protein therapeutics.
Contents
List of Corresponding Authors, Foreword, My Life with Biologicals and Nanodrugs: A Twenty-Year Affair, 1. Current Immune Aspects of Biologics and Nanodrugs: An Overview, 2. Immunological Issues with Medicines of Nano Size: The Price of Dimension Paradox, 3. Immunotherapy and Vaccines, 4. Site-Specific Antibody Conjugation for ADC and Beyond, 5. Current Understanding of Interactions between Nanoparticles and the Immune System, 6. Auto-antibodies as Biomarkers for Disease Diagnosis, 7. The Acceleated Blood Clearance Phenomenon of PEGylated Nanocarriers, 8. Anti-PEG Immunity Against PEGylated Therapeutics, 9. Complement Activation: Challenges to Nanomedicine Development, 10. Intravenous Immunoglobulin at the Borderline of Nanomedicines and Biologicals: Antithrombogenic Effect via Complement Attenuation, 11. Lessons Learned from the Porcine CARPA Model: Constant and Variable Responses to Different Nanomedicines and Administration Protocols, 12. Blood Cell Changes in Complement Activation-Related Pseudoallergy: Intertwining of Cellular and Humoral Interactions, 13. Rodent Models of Complement Activation-Related Pseudoallergy: Inducers, Symptoms, Inhibitors and Reaction Mechanisms, 14. Immune Reactions in the Delivery of RNA Interference-Based Therapeutics: Mechanisms and Opportunities, 15. Lipid Nanoparticle Induced Immunomodulatory Effects of siRNA, 16. Nanovaccines against Intracellular Pathogens Using Coxiella burnetii as a Model Organism, 17. Immunogenicity Assessment for Therapeutic Protein Products, 18. Assay Development and Validation for Immunogenicity Testing of Therapeutic Protein Products, 19. The "Sentinel": A Conceptual Nanomedical Strategy for the Enhancement of the Human Immune System, 20. Immunotherapy for Gliomas and Other Intracranial Malignancies, 21. Engineering Nanoparticles to Overcome Barriers to Immunotherapy, 22. Metal-Based Nanoparticles and theImmune System: Activation, Inflammation, and Potential Applications, 23. Silica Nanoparticles Effects on Hemostasis, 24. Valproate-Induced Rodent Model of Autism Spectrum Disorder: Immunogenic Effects and Role of Microglia, 25. Accelerated Blood Clearance Phenomenon and Complement Activation-Related Pseudoallergy: Two Sides of the Same Coin, 26. Current and Rising Concepts in Immunotherapy: Biopharmaceuticals versus Nanomedicines, 27. Characterization of the Interaction between Nanomedicines and Biological Components: In vitro Evaluation, 28. Unwanted Immunogenicity: From Risk Assessment to Risk Management, 29. Emerging Therapeutic Potential of Nanoparticles in Pancreatic Cancer: A Systematic Review of Clinical Trials, 30. SGT-53: A Novel Nanomedicine Capable of Augmenting Cancer Immunotherapy, Index
