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Full Description
Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.
Contents
Capillary Electrophoresis: A Versatile Technique in Pharmaceutical Analysis. Recent Applications of Chiral Capillary Electrophoresis in Pharmaceutical Analysis. A Mini-Review on Enantiomeric Separation of Ofloxacin using Capillary Electrophoresis: Pharmaceutical Applications. Nano-Stationary Phases for Capillary Electrophoresis Techniques. Capillary Electrophoresis Coupled to Mass Spectrometry for Enantiomeric Drugs Analysis. Enantioselective Drug-Plasma Protein-Binding Studies by Capillary Electrophoresis. Clinical Use of Capillary Zone Electrophoresis: New Insights into Parkinson's Disease. Electrophoretically Mediated Microanalysis for Evaluation of Enantioselective Drug Metabolism. Capillary Electrophoresis for the Quality Control of Intact Therapeutic Monoclonal Antibodies. Molecular Simulation of Chiral Selector-Enantiomer Interactions through Docking: Antimalarial Drugs as Case Study.
