Discovery of small-molecule modulators of protein-RNA interactions for treating cancer and COVID-19 (Springer Theses) （2023）

Byun, Wan Gi

Springer Verlag, Singapore（2023/01発売）

• 製本 Hardcover:ハードカバー版
• 言語 ENG
• 商品コード 9789811978135

Full Description

This book describes the development of novel protein-RNA-binding assays and their applications in a high-throughput manner for the identification of small-molecule modulators of protein-RNA interactions to treat cancer and COVID-19.

Modulating protein-RNA interactions with small molecules is expected to provide novel biological insights of the interrelation of diseases with the protein-RNA interactome. The modulations may also be exploited therapeutically. For these reasons, the development of a simple, reliable, and sensitive protein-RNA-binding assay is necessary for high-throughput screening to discover new effective chemical entities capable of acting on diverse protein-RNA interactions. This book discusses the discovery of small-molecule modulators targeting protein-RNA interactions that are potentially valuable to treat cancer and COVID-19 by constructing novel high-throughput screening methods. The results of this dissertation provide valuable insights into the regulation of protein-RNA interactions in chemical biology and drug development.

Contents

1. Introduction.- 2. Identification of Small-Molecule Inhibitors of Oncogenic Lin28-Let-7 Interaction.- 3. Discovery of Small-Molecule Modulators of Protein-RNA Interactions by Fluorescence Intensity-Based Binding Assay.- 4. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2.- Appendix.