Full Description
This book comprehensively reviews the proteins associated with neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It also discusses the interactions of the associated-proteins, like bromodomain-containing proteins (BCPs), kinases, synaptic proteins, scaffolding proteins, transcriptional factors, and DNA-binding proteins at the subcellular and molecular levels. The book also explores the potential of these proteins as a druggable target and a biomarker in the neurodevelopmental disorders. The book further explores the recent advancements in understanding the important role of epigenetic factors in predisposition to these diseases. Lastly, it presents genetic factors that lead to variation in gene expression in these diseases, disorders management via diet intervention and the future potential of stem cell therapy.
Contents
Chapter 1. Proteins Commonly Linked to Autism Spectrum Disorder.- Chapter 2. Protein Aggregation and Recycling.- Chapter 3. Neuron Membrane and Trafficking Protein Kinases (PKA&B) involved in ASD.- Chapter 4. Proteomic profiling in children with ASD.- Chapter 5. Molecular Protein biomarkers for developing diagnostics and therapeutic interventions.Gene Regulation in Autism. OR Neurodevelopmental Epigenomics.- Chapter 6. Chromatin and Epigenetic Regulation in ASD.- Chapter 7. Autism and the Scaffolding Protein Neurobeachin.- Chapter 8. Genomic Profiling in ADHD subjects.- Chapter 9. ADHD and Epigenetics Regulation.- Chapter 10. Proteomic Approach in ADHD.- Chapter 11. DHD and the Dopamine Transporter (DAT).- Chapter 12. Protein Kinases involved in ADHD.- Chapter 13. ADHDand Cell Adhesion Molecule 1 - CAM 1 (CADM1 gene).- Chapter 14. ASD and Cell Adhesion Molecule Astrotactin.- Chapter 15. Possible therapeutic interventions through proteins in ADHD.
