Full Description
This book reviews the role of exosomes and extracellular vesicles in both normal and pathological conditions. It first explains isolation methods for exosomes, and analyzes their fine structure and biological functions. Further, it highlights exosomes' role as the key regulator in embryonic-maternal communication, and in the pathogenesis of various diseases, including cancer and urogenital, infectious, and neurodegenerative diseases. Moreover, it reviews the latest advances in using stem-cell-derived exosomes as a cell-free strategy in regenerative medicine, as well as the potential of exosomal microRNA as a promising non-invasive biomarker and targetable factor in cancer diagnosis and treatment. Lastly, it explores the use of natural and synthetic exosomes as nano-vehicles for efficient drug delivery.
Contents
Chapter 1. Isolation and characterization of extracellular vesicles: classical and modern approaches.- Chapter 2. Characterization and fine structure of exosomes.- Chapter 3. Extracellular vesicles mediate the embryonic-maternal paracrine communication.- Chapter 4. The interplay between oviduct-derived exosomes and cumulus-oocyte complexes.- Chapter 5. The interplay between exosomes and spermatozoa.- Chapter 6. Mesenchymal stem cell-derived exosomes and regenerative medicine.- Chapter 7. Therapeutic Potential of Mesenchymal Stem/Stromal Cell Derived-Exosomes.- Chapter 8. Exosomes in Neurodegenerative Disorders.- Chapter 9. Differential expression of exosomal microRNAs in neurodegenerative diseases.- Chapter 10. Urinary exosomes as a possible source of kidney disease biomarkers.- Chapter 11. Extracellular vesicles as potential therapeutic targets and biomarkers for liver disease.- Chapter 12. Implications of extracellular vesicles in blood protozoan parasitic diseases.- Chapter 13.Cancer cells-derived Exosomes and Metastasis.- Chapter 14. Extracellular vesicles and integrins: partners in cancer progression.- Chapter 15. Exosomes: the crucial element in the prostate cancer.- Chapter 16. Exosomal microRNAs: Potential Biomarkers for Cancer Diagnosis, Treatment Response, and Prognosis.- Chapter 17. Exosomes in drug delivery.- Chapter 18. Exosomes and Supported Lipid Layers as Advanced Naturally Derived Drug Delivery Systems.
