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Full Description
This book discusses a broad range of basic and advanced topics in the field of protein structure, function, folding, flexibility, and dynamics. Starting with a basic introduction to protein purification, estimation, storage, and its effect on the protein structure, function, and dynamics, it also discusses various experimental and computational structure determination approaches; the importance of molecular interactions and water in protein stability, folding and dynamics; kinetic and thermodynamic parameters associated with protein-ligand binding; single molecule techniques and their applications in studying protein folding and aggregation; protein quality control; the role of amino acid sequence in protein aggregation; muscarinic acetylcholine receptors, antimuscarinic drugs, and their clinical significances.
Further, the book explains the current understanding on the therapeutic importance of the enzyme dopamine beta hydroxylase; structural dynamics and motions in molecularmotors; role of cathepsins in controlling degradation of extracellular matrix during disease states; and the important structure-function relationship of iron-binding proteins, ferritins. Overall, the book is an important guide and a comprehensive resource for understanding protein structure, function, dynamics, and interaction.
Contents
Chapter 1. Protein Purification, Estimation, Storage and Effect on Structure, Function and Dynamics.- Chapter 2. Experimental and Computational Methods to Determine Protein Structure and Stability.- Chapter 3. Wet-Lab Approaches to Determine Three-Dimensional Structures of Proteins.- Chapter 4. Use of Group Specific Reagents in Active Site Functional Group Elucidation I: Cys, Ser, Tyr and Trp Residues.- Chapter 5. Use of Group Specific Reagents in Active Site Functional Group Elucidation II: Asp, Glu, Arg, Lys and His residues.- Chapter 6. Protein-Protein Interactions Modeling: From Dry to Wet Lab.- Chapter 7. Thermodynamics of Protein-Ligand Binding.- Chapter 8. SynergisticEffects of Hydration Sites in Protein Stability: A Theoretical Water Thermodynamics Approach.- Chapter 9. Molecular Dynamics Simulation: Methods and Application.- Chapter 10. Protein Folding, Dynamics and Aggregation at Single Molecule Resolution.- Chapter 11. Protein Misfolding and Neurodegenerative Diseases.- Chapter 12. Management of Insulin Through Co-Solute Engineering: A Therapeutic Approach.- Chapter 13. Structural and Functional Aspects of Muscarinic Receptors in Correlation with Anticholinergic Drugs.- Chapter 14. Dopamine Β Hydroxylase: An Enzyme with Therapeutic Potential to Combat Neural and Cardiovascular Diseases.- Chapter 15. Molecular Motors: Subdomain Dynamics and Mechanochemistry.- Chapter 16. Structural and Functional Dynamics of Lysosomal Cysteine Proteases with Particular Reference to Cathepsin B and Cathepsin H.- Chapter 17. An Insight into the Importance of Ferritins in the Physiology of Mycobacterium tuberculosis: Unique Structural and Functional Properties.
