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Full Description
With the rapid development of biotechnologies, single-cell sequencing has become an important tool for understanding the molecular mechanisms of diseases, defining cellular heterogeneities and characteristics, and identifying intercellular communications and single-cell-based biomarkers. Providing a clear overview of the clinical applications, the book presents state-of-the-art information on immune cell function, cancer progression, infection, and inflammation gained from single-cell DNA or RNA sequencing. Furthermore, it explores the role of target gene methylation in the pathogenesis of diseases, with a focus on respiratory cancer, infection and chronic diseases. As such it is a valuable resource for clinical researchers and physicians, allowing them to refresh their knowledge and improve early diagnosis and therapy for patients.
Contents
Values of single-cell sequencing and methylation in molecular diagnosis and therapy.- Single-cell sequencing in human diseases.- Single-cell sequencing of T cell receptors: A perspective on the technological development and translational application.- DNA Methylation in pulmonary fibrosis.- Molecular regulation and clinical significance of caveolin-1 methylation in chronic lung diseases.- Research advances on DNA methylation in idiopathic pulmonary fibrosis.- DNA Methylation in Chronic Obstructive Pulmonary Disease.- Single cell sequencing: a new dimension in cancer diagnosis.- The Role of Methylation in the CpG Island of the ARHI Promoter Region in Cancers.- Clinical Significance of P16 Gene Methylation in Lung Cancer.- Application of single-cell RNA sequencing in pancreatic cancer and the endocrine pancreas.- Single Cell Sequencing in GU Malignancies.- PI3K Isoform-Selective Inhibitors in Cancer.- Single cell RNA sequencing in human disease: Renal, pancreatic, and viral diseases.- Single-cell sequencing in human genital infections.- PI3kinase Inhibitors in Thrombosis and Cardiovascular Disease.- Use of single-cell microfluidic technology towards therapeutic antibody discovery from single B cells.
